ChemicalBook > CAS DataBase List > 1H-1,2,4-Triazole-3,5-diamine

1H-1,2,4-Triazole-3,5-diamine

Product Name
1H-1,2,4-Triazole-3,5-diamine
CAS No.
1455-77-2
Chemical Name
1H-1,2,4-Triazole-3,5-diamine
Synonyms
3,5-DIAMINO-1,2,4-TRIAZOLE;GUANAZOLE;4H-1,2,4-TRIAZOLE-3,5-DIAMINE;nsc1895;MC 51762;NSC 1895;NCI-C04819;TIMTEC-BB SBB004371;Guanazole (VAN) (8CI);3,5-diamino-s-triazol
CBNumber
CB3756001
Molecular Formula
C2H5N5
Formula Weight
99.09
MOL File
1455-77-2.mol
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1H-1,2,4-Triazole-3,5-diamine Property

Melting point:
202-205 °C (lit.)
Boiling point:
473.7±28.0 °C(Predicted)
Density 
1.686±0.06 g/cm3(Predicted)
refractive index 
1.7330 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: clear to hazy
form 
powder
pka
12.10±0.40(Predicted)
color 
white
Water Solubility 
Soluble in water.
BRN 
112467
Stability:
Stability Air sensitive. Reacts with acids and oxidizing agents.
InChIKey
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
CAS DataBase Reference
1455-77-2(CAS DataBase Reference)
NIST Chemistry Reference
3,5-Diamino-1,2,4-triazole(1455-77-2)
EPA Substance Registry System
Guanazole (1455-77-2)
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Safety

Hazard Codes 
Xn,Xi,C
Risk Statements 
22-34
Safety Statements 
36/37-45-36/37/39-27-26
WGK Germany 
3
RTECS 
XZ4535000
TSCA 
Yes
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D26202
Product name
3,5-Diamino-1,2,4-triazole
Purity
98%
Packaging
25g
Price
$195
Updated
2025/07/31
Sigma-Aldrich
Product number
D26202
Product name
3,5-Diamino-1,2,4-triazole
Purity
98%
Packaging
100g
Price
$704
Updated
2025/07/31
TCI Chemical
Product number
D2587
Product name
3,5-Diamino-1,2,4-triazole
Purity
>97.0%(T)
Packaging
5g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
D2587
Product name
3,5-Diamino-1,2,4-triazole
Purity
>97.0%(T)
Packaging
25g
Price
$128
Updated
2025/07/31
TRC
Product number
D415265
Product name
3,5-Diamino-1,2,4-triazole
Packaging
25g
Price
$275
Updated
2021/12/16
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1H-1,2,4-Triazole-3,5-diamine Chemical Properties,Usage,Production

Chemical Properties

colourless crystals or faintly yellow powder

Uses

3,5-Diamino-1,2,4-triazole is used as an inhibitor of DNA synthesis. It also serves as an antitumor agents in the treatment of epigenetically-based diseases. It acts as a corrosion inhibitor for copper.

Definition

ChEBI: An aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups.

General Description

Colorless crystals.

Air & Water Reactions

1H-1,2,4-Triazole-3,5-diamine is sensitive to air. Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reactivity Profile

The triazoles, of which 1H-1,2,4-Triazole-3,5-diamine is a member, are a group of highly explosive materials that are sensitive to heat, friction, and impact. Sensitivity varies with the type of substitution to the triazole ring. The amine substituted derivatives, 1H-1,2,4-Triazole-3,5-diamine, tend not to be explosion sensitive. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. 1H-1,2,4-Triazole-3,5-diamine forms salts readily with acids.

Health Hazard

SYMPTOMS: 1H-1,2,4-Triazole-3,5-diamine is stable under normal laboratory conditions.

Fire Hazard

Flash point data for 1H-1,2,4-Triazole-3,5-diamine are not available. 1H-1,2,4-Triazole-3,5-diamine is probably combustible.

Safety Profile

Human systemic effects by intravenous route: leukopenia (reduced white blood cell count) and thrombo cytopenia (reduced blood platelet count). Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

127099-85-8

1455-77-2

1. 500 mL of water was added to a 2000 mL three-necked flask and 200.0 g of dicyandiamide was added with vigorous stirring for 20 minutes to form a turbid liquid. 2. 155 g of hydrazine sulfate was added to the cloudy liquid and the mixture was heated to 50°C. 3. 72 mL of 80% water was added slowly. 3. 72 mL of 80% hydrazine hydrate was added slowly, followed by warming the reaction system to 120°C to 125°C, during which all solids gradually dissolved. 4. the reaction mixture was stirred continuously at 120°C to 125°C for 16 hours, during which time a small amount of solids precipitated out of solution. 5. Upon completion of the reaction, the heating was stopped and the reaction mixture was cooled to room temperature. 6. The pH of the reaction mixture was adjusted to 9 by adding 100 mL of 10% sodium carbonate solution. 7. The reaction mixture was transferred to a 2 L dispensing funnel and the organic phase was extracted with 500 mL of dichloromethane. 8. The organic phase was washed with water and dried with anhydrous sodium sulfate. 9. Dichloromethane was removed by evaporation to give a white solid product. 10. The white solid was dried in a hot air oven to give a final product of 169 g of 3,5-diamino-1,2,4-triazole in 72% yield based on dicyandiamide.

Purification Methods

The triazole crystallises from water or EtOH. [Beilstein 26 III/IV 1161.]

References

[1] Patent: CN105968058, 2016, A. Location in patent: Paragraph 0073; 0074; 0075
[2] Chemische Berichte, 1912, vol. 45, p. 2733
[3] Journal fuer Praktische Chemie (Leipzig), 1913, vol. <2>88, p. 312
[4] Gazzetta Chimica Italiana, 1894, vol. 24, p. I 491
[5] Chemistry - A European Journal, 2010, vol. 16, # 5, p. 1572 - 1584

1H-1,2,4-Triazole-3,5-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-1,2,4-Triazole-3,5-diamine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Hebei Yanxi Chemical Co., Ltd.
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
1H-1,2,4-Triazole-3,5-diamine 1455-77-2
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20

1455-77-2, 1H-1,2,4-Triazole-3,5-diamineRelated Search:

1H-1,2,4-Triazole-3,5-diamine 3,5-DIAMINO-1,2,4-TRIAZOLE,3,5-diamino-1,3,5-triazole,3 5-DIAMINO-1 2 4-TRIAZOLE 98% 1,2,4-Triazole 3,5,7-TRIAMINO-1,2,4-TRIAZOLO[4,3-A]-1,3,5-TRIAZINE N3-(4-CHLOROPHENYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE N3,N3,N5,N5-TETRAMETHYL-1-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1-phenyl-1H-1,2,4-triazole-3,5-diamine 1-(4-FLUOROBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1-(2,6-DICHLOROBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 1H-1,2,4-Triazole-3,5-diamine,N-propyl-(9CI) N-phenyl-1H-1,2,4-triazole-3,5-diamine 1-[(4-METHOXYPHENYL)SULFONYL]-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE N3,N3,N5,N5-TETRAMETHYL-1-(4-METHYLBENZYL)-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 4H-1,2,4-Triazole-3,4-diamine,5-ethyl-N-methyl-N-(phenylmethylene)-(9CI) 5-METHYL-1,2,4-TRIAZOLE-3,4-DIAMINE 4H-1,2,4-Triazole-3,4-diamine 1-(4-BROMOBENZYL)-N3,N3,N5,N5-TETRAMETHYL-1H-1,2,4-TRIAZOLE-3,5-DIAMINE 7-(4-BROMOPHENYL)-2-MORPHOLINO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE

  • 3,5-DiaMino-1,2,4-triazole, 98% 25GR
  • 3,5-Diamino-1H-1,2,4-triazole, Guanazole
  • 1,2,4-triazolidine-3,5-diiMine
  • Guanazole SynonyMs 1H-1,2,4-Triazole-3,5-diaMine
  • (5-amino-2H-1,2,4-triazol-3-yl)amine
  • Guanazole (VAN) (8CI)
  • 4H-1,2,4-TRIAZOLE-3,5-DIAMINE
  • 3-AMINO-1H-1,2,4-TRIAZOL-5-YLAMINE
  • 3,5-DIAMINO-1,2,4-TRIAZOLE
  • 3,5-DIAMINO-1H-1,2,4-TRIAZOLE
  • 1,2,4-Triazolidine, 3,5-diimino-
  • 3,5-diamino-s-triazol
  • 3,5-Diamino-s-triazole
  • MC 51762
  • NCI-C04819
  • NSC 1895
  • nsc1895
  • s-Triazole, 3,5-diamino-
  • GUANAZOLE
  • TIMTEC-BB SBB004371
  • 1H-1,2,4-TRIAZOLE-3,5-DIAMINE
  • 3,5-Diamino-1,2,4-triazole (Guanazole)
  • 1H-1,2,4-Triazole-3,5-diamine (Guanazole)
  • GUANETIDINEHEMISULPHATE
  • 3,5-DIAMINO-1,2,4-TRIAZOLE, 98+%
  • 2,3-Diamino-1H-1,2,4-triazole
  • Guanazole 3,5-Diamino-1,2,4-triazole (Guanazole) 3,5-Diamino-1H-1,2,4-triazole 1H-1,2,4-triazole-3,5-diamine
  • 3,5-Diamino-1,2,4-triazole, 98%, for synthesis
  • 3,5-Diamino-1,2,4-triazole&gt
  • 3,5-Diamino-1,2,4-triazole C
  • H-1,2,4-Triazole-3,5-diamine
  • 1455-77-2
  • 1455-72-2
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