ChemicalBook > CAS DataBase List > (R)-N-BOC-3-AMINOBUTYRIC ACID

(R)-N-BOC-3-AMINOBUTYRIC ACID

Product Name: (R)-N-BOC-3-AMINOBUTYRIC ACID
CAS No.: 159991-23-8
Chemical Name: (R)-N-BOC-3-AMINOBUTYRIC ACID
Synonyms: (R)-3-((tert-Butoxycarbonyl)aMino)butanoic acid;Boc-d-β-hoala-oh;BOC-D-B-HOMOALA-OH;(R)-BOC-B2-HOALA-OH;RARECHEM AK PT F080;Boc-D-b-homoalanine;Boc-D-β-Homo-Ala-OH;Boc-D-beta-HoAla-OH;Boc-D-β-Homoalanine;(R)-BOC-BETA2-HAL-OH
CBNumber: CB3763836
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 159991-23-8.mol

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(R)-N-BOC-3-AMINOBUTYRIC ACID Property

Melting point:: 104-107 °C
Boiling point:: 339.5±25.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.43±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure
InChI: InChI=1S/C9H17NO4/c1-6(5-7(11)12)10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m1/s1
InChIKey: PYNDHEONPQYIAN-ZCFIWIBFSA-N
SMILES: C(O)(=O)C[C@H](NC(OC(C)(C)C)=O)C
CAS DataBase Reference: 159991-23-8(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T117605
Product name: (R)-3-(tert-Butoxycarbonylamino)butanoicAcid
Packaging: 1g
Price: $105
Updated: 2021/12/16

Usbiological

Product number: 265644
Product name: Boc-D-beta-homoalanine
Packaging: 250mg
Price: $358
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0011968
Product name: (R)-3-TERT-BUTOXYCARBONYLAMINO-BUTYRIC ACID
Purity: 95.00%
Packaging: 1G
Price: $848.93
Updated: 2021/12/16

Iris Biotech GmbH

Product number: BAA6090
Product name: Boc-D-beta-HAla-OH
Packaging: 5G
Price: $1593
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0011968
Product name: (R)-3-TERT-BUTOXYCARBONYLAMINO-BUTYRIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1758.49
Updated: 2021/12/16

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(R)-N-BOC-3-AMINOBUTYRIC ACID Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

(R)-3-(tert-Butoxycarbonylamino)butanoic Acid is a non-proteinogenic amino acid that can be used to synthesize peptide analogs.

Synthesis

3775-73-3

24424-99-5

159991-23-8

General steps: 1. suspend (R)-3-aminobutyric acid (2.415 g, 23.42 mmol) in a solvent mixture of dioxane (15 mL) and water (15.00 mL) at room temperature with stirring. 2. Triethylamine (TEA, 4.90 mL, 35.1 mmol) was added dropwise to the suspension to give a light brown solution. 3. The reaction mixture was cooled to 0 °C and di-tert-butyl dicarbonate (4.69 g, 26.9 mmol) was added in one portion. 4. The reaction mixture was stirred at room temperature for 16 hours. 5. 5. Upon completion of the reaction, the mixture was partitioned between water (80 mL) and ethyl acetate (EtOAc, 80 mL). 6. The aqueous layer was separated and washed with EtOAc. 7. The aqueous layer was acidified to pH=3 with 1 M aqueous KHSO4 and extracted with EtOAc (2 x 80 mL). 8. The EtOAc extracts were combined, washed with saturated aqueous NaCl (2 x 80 mL), dried over anhydrous Na2SO4, filtered and concentrated. 9. (R)-3-((tert-butoxycarbonyl)amino)butyric acid (4.301 g, 21.16 mmol, 90% yield) was obtained as a pale yellow solid. 10. The product was characterized by XH NMR (400 MHz, CDCl3): δ 4.92 (s, 1H), 4.14-3.96 (m, 2H), 2.56 (d, J=5.2 Hz, 2H), 1.45 (s, 9H), 1.25 (d, J=6.9 Hz, 3H).

References

[1] Patent: WO2012/125622, 2012, A1. Location in patent: Page/Page column 135-136
[2] Chinese Chemical Letters, 2015, vol. 26, # 1, p. 103 - 107
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 5, p. 1421 - 1425
[4] Angewandte Chemie - International Edition, 2018, vol. 57, # 31, p. 9707 - 9710
[5] Angew. Chem., 2018, vol. 130, # 31, p. 9855 - 9858,4

(R)-N-BOC-3-AMINOBUTYRIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-BOC-3-AMINOBUTYRIC ACID Suppliers

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View Lastest Price from (R)-N-BOC-3-AMINOBUTYRIC ACID manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (R)-N-BOC-3-AMINOBUTYRIC ACID 159991-23-8
Price: US $150.00-1500.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-23

159991-23-8, (R)-N-BOC-3-AMINOBUTYRIC ACIDRelated Search:

Boc-L-aspartic acid 4-benzyl ester Boc-Asp-OH Boc-L-aspartic acid 4-tert-butyl ester Boc-L-aspartic acid 1-benzyl ester 4-tert-Butyl N-[(tert-butoxy)carbonyl]-L-aspartate dicyclohexylamine salt Boc-Asp(Ochx)-OH BOC-ASP(OBZL)-OSU Boc-Asp-OtBu BOC-ASP(OTBU)-OSU (S)-N-BOC-3-AMINOBUTYRIC ACID BOC-D-AMINOBUTYRIC ACID BOC-GAMMA-ABU-OH BOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID BOC-ASP-OCHEX DCHA BOC-ASP(OCPENT)-OH BOC-(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID (2S,3R)-3-(BOC-AMINO)-2-HYDROXY-4-(4-NITROPHENYL)BUTYRIC ACID BOC-ASP-TYR-MET-GLY-TRP-MET-ASP-PHE-NH2

BOC-D-BETA-HOMOALANINE

BOC-D-B-HOMOALA-OH

BOC PROTECTED (R)-B-AMINOBUTYRIC ACID

(R)-N-BOC-3-AMINOBUTYRIC ACID

(R)-N-(TERT-BUTOXYCARBONYL)-3-AMINOBUTYRIC ACID

3-N-BOC-3-(R)-AMINO BUTYRIC ACID

(3R)-3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]butanoic acid

(3R)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid

(R)-BOC-B2-HOALA-OH

(R)-BOC-BETA2-HAL-OH

(R)-BOC-BETA2-HOMOALANINE

RARECHEM AK PT F080

(R)-3-TERT-BUTOXYCARBONYLAMINO-BUTYRIC ACID

(R)-3-(BOC-AMINO)-BUTYRIC ACID

Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (3R)- (9CI)

(R)-3-((tert-Butoxycarbonyl)aMino)butanoic acid

Boc-D-b-homoalanine

Boc-D-β-Homo-Ala-OH

(R)-3-(Boc-amino)butanoic acid

Boc-D-BETA-Homo-Ala-OH

Boc-D-beta-HoAla-OH

(R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]butanoic acid

Boc-D-β-homoalanine≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl D-β-homoalanine

(3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

(R)-3-(Boc-amino)butyric acid, 98% white powder

Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (3R)-

N-β-(t-Butoxycarbonyl)-D-β-homoalanine

(R)-3-amino-butanoicacidmethylester HCl

Boc-d-β-hoala-oh

Boc-D-β-Homoalanine

(3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]butanoic acid

Boc-R-3-Aminobutyric acid

(R)-N-BOC-3-AMINOBUTYRIC ACID, 98%min

159991-23-8

Amino Acid

N-BOC

Beta amino acids

pharmacetical