(S)-N-Boc-3-aminobutyric acid
- Product Name
- (S)-N-Boc-3-aminobutyric acid
- CAS No.
- 158851-30-0
- Chemical Name
- (S)-N-Boc-3-aminobutyric acid
- Synonyms
- -HoAla-OH;Boc--HoAla-OH;Boc-b-HoAla-OH;BOC-SS-HOMOALA;Boc-β-HoAla-OH;CAS:158851-30-0;Boc-L-β-Homo-Ala;Boc-p-HomoAla-OH;Boc-beta-HAla-OH;Boc-L-b-HoAla-OH
- CBNumber
- CB3158869
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 158851-30-0.mol
(S)-N-Boc-3-aminobutyric acid Property
- Melting point:
- 99 °C
- Boiling point:
- 339.5±25.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.43±0.10(Predicted)
- color
- White to light yellow
- optical activity
- Consistent with structure
- Water Solubility
- Slightly soluble in water.
- BRN
- 6800577
- InChI
- InChI=1S/C9H17NO4/c1-6(5-7(11)12)10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m0/s1
- InChIKey
- PYNDHEONPQYIAN-LURJTMIESA-N
- SMILES
- C(O)(=O)C[C@@H](NC(OC(C)(C)C)=O)C
- CAS DataBase Reference
- 158851-30-0(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 14974
- Product name
- Boc-β-Homoala-OH
- Purity
- ≥98.0% (TLC)
- Packaging
- 1g
- Price
- $197
- Updated
- 2023/06/20
- Product number
- B656210
- Product name
- Boc-β-Homoala-OH
- Packaging
- 1g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- BAA6120
- Product name
- Boc-L-beta-HAla-OH
- Packaging
- 1g
- Price
- $364.5
- Updated
- 2021/12/16
- Product number
- FB46525
- Product name
- (S)-N-Boc-3-aminobutyric acid
- Packaging
- 5G
- Price
- $370
- Updated
- 2021/12/16
- Product number
- CS-W015456
- Product name
- (S)-3-((tert-Butoxycarbonyl)amino)butanoicacid
- Purity
- ≥97.0%
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
(S)-N-Boc-3-aminobutyric acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
(S)-3-(Boc-amino)butyric acid is used for the syntheses of aza-analogues of macrosphelides, synthesis of hybrid peptides with 12/10-helix, and in the synthesis of potentially pharmaceutically active products for the treatment of auto-immune and inflammatory diseases.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
118173-26-5
158851-30-0
Under argon protection, sodium dihydrogen phosphate (7.0 g) and 34.5% aqueous hydrogen peroxide solution (20 mL) were sequentially added to a solution of tert-butyl (S)-(4-oxobutan-2-yl)carbamate (7.3 g, 39.0 mmol) in acetonitrile (50 mL), and the reaction mixture was stirred at 0 °C for 10 min. Subsequently, a solution of sodium chlorite (6.0 g) in water (20 mL) was added dropwise to the reaction system and stirring was continued at 0 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and the aqueous phase was washed with dichloromethane. The aqueous layer was acidified with 10% hydrochloric acid and extracted with dichloromethane, the organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was identified by 1H-NMR as carboxylic acid (8) (6.0 g, 29.6 mmol, 76% yield), which could be used in the next reaction without further purification.
References
[1] Tetrahedron, 2011, vol. 67, # 40, p. 7681 - 7685
(S)-N-Boc-3-aminobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-N-Boc-3-aminobutyric acid manufacturers
- Product
- (S)-N-Boc-3-aminobutyric acid 158851-30-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- (S)-N-Boc-3-aminobutyric acid 158851-30-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22