ChemicalBook > CAS DataBase List > 4-Bromothiophene-2-carboxaldehyde

4-Bromothiophene-2-carboxaldehyde

Product Name
4-Bromothiophene-2-carboxaldehyde
CAS No.
18791-75-8
Chemical Name
4-Bromothiophene-2-carboxaldehyde
Synonyms
4-BROMOTHIOPHENE-2-CARBALDEHYDE;4-BROMO-2-THIOPHENECARBOXALDEHYDE;TIMTEC-BB SBB000293;4-Bromo-2-thiophene;LABOTEST-BB LT00112358;4-BROMO-2-FORMYLTHIOPHENE;3-Bromo-5-formylthiophene;4-BROMOTHIOPHENE-2-ALDEHYDE;4-Bromthiophen-2-carbaldehyd;4-BROMO-2-THIOPHENECARBALDEHYDE
CBNumber
CB3771198
Molecular Formula
C5H3BrOS
Formula Weight
191.05
MOL File
18791-75-8.mol
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4-Bromothiophene-2-carboxaldehyde Property

Melting point:
44-46 °C (lit.)
Boiling point:
114-115 °C/11 mmHg (lit.)
Density 
1.770 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
Powder or Granules
color 
White to beige
Sensitive 
Air Sensitive
BRN 
108455
InChI
InChI=1S/C5H3BrOS/c6-4-1-5(2-7)8-3-4/h1-3H
InChIKey
PDONIKHDXYHTLS-UHFFFAOYSA-N
SMILES
C1(C=O)SC=C(Br)C=1
CAS DataBase Reference
18791-75-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-20/21/22
Safety Statements 
22-24/25-36/37/39-26-36
WGK Germany 
3
F 
10-23
TSCA 
N
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
283452
Product name
4-Bromo-2-thiophenecarboxaldehyde
Purity
90%
Packaging
5g
Price
$56.3
Updated
2025/07/31
Sigma-Aldrich
Product number
283452
Product name
4-Bromo-2-thiophenecarboxaldehyde
Purity
90%
Packaging
25g
Price
$186.9
Updated
2025/07/31
TCI Chemical
Product number
B2827
Product name
4-Bromothiophene-2-carboxaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
B2827
Product name
4-Bromothiophene-2-carboxaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$119
Updated
2025/07/31
TRC
Product number
B688110
Product name
4-Bromo-2-thiophenecarboxaldehyde
Packaging
50g
Price
$1230
Updated
2021/12/16
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4-Bromothiophene-2-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Bromothiophene-2-carboxaldehyde has been used:

  • as building block for the synthesis of tetrahydroisoquinolinones
  • in the synthesis of 3-[(4-bromo-2-thienyl)methylenehydrazinocarbonyl]-1H-1,2,4-triazole

Application

4-Bromothiophene-2-carboxaldehyde is an important and commonly used intermediate in medicinal chemistry.

Synthesis

872-31-1

68-12-2

18791-75-8

930-96-1

General procedure: a THF solution of 1 M NaHMDS (8.8 mL, 8.8 mmol) was slowly added dropwise to the substrate (6.8 mmol) at 0°C. The reaction mixture was stirred for 30 min at 0 °C, then a solution of anhydrous THF (2 mL) with electrophilic reagent (8.3 mmol) was slowly added and stirring was continued for 3 h at 0 °C. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (5 mL) and diluted with hexane (20 mL). The organic layer was separated and washed with 15 wt% NaCl aqueous solution (10 mL) and subsequently concentrated to give the crude product. The product was purified by fast chromatography using a silica gel column pretreated with Et3N and 0.1% Et3N/4.9% EtOAc/95% hexane as eluent.

Toxicity evaluation

4-Bromothiophene-2-carboxaldehyde has acute oral toxicity and acute dermal toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169
[2] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169

4-Bromothiophene-2-carboxaldehyde Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Aluminum chloride Bromine Dichloromethane

Preparation Products

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4-Bromothiophene-2-carboxaldehyde Suppliers

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View Lastest Price from 4-Bromothiophene-2-carboxaldehyde manufacturers

Shandong Vital Biotechnology Co., Ltd.
Product
4-BroMo-2-thiophenecarboxaldehyde 18791-75-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100tons
Release date
2025-11-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Bromothiophene-2-carboxaldehyde 18791-75-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Bromothiophene-2-carboxaldehyde 18791-75-8
Price
US $9.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-19

18791-75-8, 4-Bromothiophene-2-carboxaldehydeRelated Search:

2-Thiophenecarboxaldehyde Tetrahydrothiophene Cephalothin sodium Thifensulfuron 3-Thiophenecarboxaldehyde Dibenzothiophene Bromine 5-BROMOTHIOPHENE-2-CARBOXALDEHYDE,2-BROMOTHIOPHENE-5-CARBOXALDEHYDE 5-BROMOTHIOPHENE-2-CARBOXALDEHYDE OXIME 3-Bromothiophene-2-carboxaldehyde, GC 97%,3-BROMOTHIOPHENE-2-CARBOXALDEHYDE 98%,3-Bromothiophene-2-carboxaldehyde, 95%+,3-BROMOTHIOPHENE-2-CARBOXALDEHYDE 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 3-BROMOTHIOPHENE-2-CARBOXALDEHYDE DIETHYL ACETAL METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID METHYL 4,5-DIBROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE METHYL 4-BROMO-3-METHOXYTHIOPHENE-2-CARBOXYLATE

  • 4-Bromo-2-thiophenecarboxaldehyde,90%
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  • 4-Bromothiophene-2-carboxaldehyde 98%
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  • 4-BROMO-2-FORMYLTHIOPHENE
  • 4-Bromothiophen-2-carboxaldehyde
  • TIMTEC-BB SBB000293
  • LABOTEST-BB LT00112358
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  • 2-THIOPHENE-4-BROMOCARBOXALDEHYDE
  • 4-Bromo-2-thiophene
  • 4-BROMO-2-THIOPHENECARBOXALDEHYDE 90%
  • 4-Bromothiophene-2-carboxaldehyde &gt
  • 4-Bromothiophene-2-carboxaldehyde ISO 9001：2015 REACH
  • 4-Bromthiophen-2-carbaldehyd
  • 3-Bromo-5-formylthiophene
  • 18791-75-8
  • C5H3BrOS
  • C5H3OBrS
  • ALDEHYDE
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Thiophenes
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Thiophenes
  • ThiophenesBuilding Blocks
  • Aldehyde
  • Building Blocks
  • Thiophene
  • Aldehydes
  • blocks
  • Bromides
  • Heterocycles
  • Carbonyl Compounds
  • Thiophene&Benzothiophene