2'-Hydroxychalcone
- Product Name
- 2'-Hydroxychalcone
- CAS No.
- 1214-47-7
- Chemical Name
- 2'-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-HYDROXYCHALCONE;2'-hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone;2'-HYDROXYCHALCONE 1214-47-7
- CBNumber
- CB3771305
- Molecular Formula
- C15H12O2
- Formula Weight
- 224.25
- MOL File
- 1214-47-7.mol
2'-Hydroxychalcone Property
- Melting point:
- 86-88 °C(lit.)
- Boiling point:
- 396.6±42.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Store below +30°C.
- pka
- 7.77±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- BRN
- 976324
- LogP
- 4.000 (est)
- CAS DataBase Reference
- 1214-47-7(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 8.14776
- Product name
- 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $69.8
- Updated
- 2024/03/01
- Product number
- S449725
- Product name
- 2'-HYDROXYCHALCONE
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 8.14776
- Product name
- 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $216
- Updated
- 2024/03/01
- Product number
- H0385
- Product name
- 2'-Hydroxychalcone
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- L13937
- Product name
- 2'-Hydroxychalcone, 98+%
- Packaging
- 5g
- Price
- $32.8
- Updated
- 2024/03/01
2'-Hydroxychalcone Chemical Properties,Usage,Production
Chemical Properties
Yellow needle-like crystals (ethanol). Melting point 88-89°C.
Uses
2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.
Definition
ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.
Preparation
Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.
2'-Hydroxychalcone Preparation Products And Raw materials
Raw materials
Preparation Products
2'-Hydroxychalcone Suppliers
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View Lastest Price from 2'-Hydroxychalcone manufacturers
- Product
- 2'-Hydroxychalcone 1214-47-7
- Price
- US $85.00-850.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-01
- Product
- 2'-Hydroxychalcone 1214-47-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 500tons
- Release date
- 2021-07-09
- Product
- 2'-HYDROXYCHALCONE 1214-47-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30