2'-Hydroxychalcone

Product Name: 2'-Hydroxychalcone
CAS No.: 1214-47-7
Chemical Name: 2'-Hydroxychalcone
Synonyms: 2-HYDROXYCHALC;O-CINNAMOYLPHENOL;6'-Hydroxychalcone;2'-HYDROXYCHALCONE;2'-hydroxychalcone;HYDROXYCHALCONE, 2'-;2'-HYDROXYCHALCONE 98%;2-HYDROXYBENZALACETOPHENONE;2-Hydroxyphenylstyryl ketone;2'-HYDROXYCHALCONE 1214-47-7
CBNumber: CB3771305
Molecular Formula: C15H12O2
Formula Weight: 224.25
MOL File: 1214-47-7.mol

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2'-Hydroxychalcone Property

Melting point:: 86-88 °C(lit.)
Boiling point:: 396.6±42.0 °C(Predicted)
Density: 1.191±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Store below +30°C.
pka: 7.77±0.30(Predicted)
form: Solid
color: Light yellow to yellow
BRN: 976324
LogP: 4.000 (est)
CAS DataBase Reference: 1214-47-7(CAS DataBase Reference)
EPA Substance Registry System: 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: UD5579400
F: 8
Autoignition Temperature: 280 °C
TSCA: Yes
HS Code: 29145090
Toxicity: mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.14776
Product name: 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
Purity: for synthesis
Packaging: 25g
Price: $69.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: S449725
Product name: 2'-HYDROXYCHALCONE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14776
Product name: 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
Purity: for synthesis
Packaging: 100g
Price: $216
Updated: 2024/03/01

TCI Chemical

Product number: H0385
Product name: 2'-Hydroxychalcone
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $68
Updated: 2021/12/16

Alfa Aesar

Product number: L13937
Product name: 2'-Hydroxychalcone, 98+%
Packaging: 5g
Price: $32.8
Updated: 2024/03/01

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2'-Hydroxychalcone Chemical Properties,Usage,Production

Chemical Properties

Yellow needle-like crystals (ethanol). Melting point 88-89°C.

Uses

2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.

Definition

ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.

Preparation

Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.

2'-Hydroxychalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Hydroxychalcone Suppliers

Belgium 1 China 155 Europe 1 France 1 Germany 5 India 26 Japan 2 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 13 United States 24 Global 232

HBCChem, Inc.

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View Lastest Price from 2'-Hydroxychalcone manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 2'-Hydroxychalcone 1214-47-7
Price: US $85.00-850.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-01

Wuhan Boyuan Import & Export Co., LTD

Product: 2'-Hydroxychalcone 1214-47-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500tons
Release date: 2021-07-09

Henan Fengda Chemical Co., Ltd

Product: 2'-HYDROXYCHALCONE 1214-47-7
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

1214-47-7, 2'-HydroxychalconeRelated Search:

Quercetin Myricetin Diosmin Apigenin DULCITOL FLAVONE DIMETHOXY-2'-HYDROXYCHALCONE, 2,3-,2,3-DIMETHOXY-2'-HYDROXYCHALCONE 7-HYDROXYFLAVONE Rutin MORIN Hesperidin methylchalcone Chrysin α-Naphthoflavone Galangin 3-HYDROXYFLAVONE 2'-Hydroxychalcone 7,8-Dihydroxyflavone 4-HYDROXYCHALCONE,HYDROXYCHALCONE, 4-

2μ-Hydroxychalcone, 2-Hydroxybenzalacetophenone

2-Hydroxyphenylstyryl ketone

6'-Hydroxychalcone

2-Benzal-2'-hydroxyacetophenone 2-Benzylidene-2'-hydroxyacetophenone

3-Phenyl-1-(2-hydroxyphenyl)-2-propen-1-one

2-HYDROXYCHALC

(E)-1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE

HYDROXYCHALCONE, 2'-

BENZYLIDENE-(2-HYDROXYACETOPHENONE)

Phenylvinylo-hydroxyphenylketone

O-CINNAMOYLPHENOL

Benzylidene(2-hydroxyacetophenone)~1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one

2'-HYDROXYCHALCONE 98%

2-HYDROXYCHALCONE(2'-HYDROXYISOMER)

BENZYLIDENE-2'-HYDROXYACETOPHENONE

2-BENZAL-2'-HYDROXYACETOPHENONE

2-BENZYLIDENE-2'-HYDROXYACETOPHENONE

2'-HYDROXYCHALCONE

2-HYDROXYBENZALACETOPHENONE

1-(2-HYDROXYPHENYL)-3-PHENYL-2-PROPEN-1-ONE

1-(2-HYDROXYPHENYL)-3-PHENYL-2-PROPENONE

1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE

1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-on

2’-hydroxy-3-phenyl-acrylophenon

2-<WBR>Hydroxybenzalacetophenone

2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl-

2-HydroxychalconeQ: What is 2-Hydroxychalcone Q: What is the CAS Number of 2-Hydroxychalcone Q: What is the storage condition of 2-Hydroxychalcone Q: What are the applications of 2-Hydroxychalcone

2'-HYDROXYCHALCONE 1214-47-7

2'-hydroxychalcone

1214-47-7

C6H5CHCHCOC6H4OH

Flavonoids

Chalcones, etc. (Building Blocks for Liquid Crystals)

Building Blocks for Liquid Crystals

Organic Building Blocks

Ketones

Building Blocks

C15 to C38

Carbonyl Compounds

Biochemistry

Building Blocks for Liquid Crystals

Chalcones, etc. (Building Blocks for Liquid Crystals)

Flavonoids

Functional Materials