LEUKOTRIENE A3 METHYL ESTER Property

Flash point:

-26 °C

storage temp. 

−20°C

solubility 

DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml

form 

Colorless liquid.

Safety

Hazard Codes 

F,Xn,N

Risk Statements 

11-38-48/20-51/53-62-65-67

Safety Statements 

36/37-61-62-16

RIDADR 

UN 1208 3/PG 2

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P331Do NOT induce vomiting.

LEUKOTRIENE A3 METHYL ESTER Chemical Properties,Usage,Production

Description

Biosynthesis of LTA₃ occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA₃ as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

Uses

LTA3 (Leukotriene A3 methyl ester) is a suicide inhibitor of LTA4 hydrolase.