ChemicalBook > CAS DataBase List > alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

Product Name
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
CAS No.
24155-42-8
Chemical Name
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
Synonyms
Imidazole alcohol;1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANOL;t824;r14821;MIC III;SQ-13283;1-[2-(2,4-DichL;)-2-hydroxyethyL;IMIDAZOLE ETHANOL;MICONAZOLE EP IMP A
CBNumber
CB3780543
Molecular Formula
C11H10Cl2N2O
Formula Weight
257.12
MOL File
24155-42-8.mol
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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Property

Melting point:
134-138 °C
Boiling point:
468.5±45.0 °C(Predicted)
Density 
1.4133 (rough estimate)
vapor pressure 
0Pa at 20℃
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.25±0.20(Predicted)
form 
solid
color 
White to Pale Yellow
Water Solubility 
1300 g/L (20 ºC)
InChIKey
UKVLTPAGJIYSGN-UHFFFAOYSA-N
LogP
2.31 at 20℃
CAS DataBase Reference
24155-42-8(CAS DataBase Reference)
EPA Substance Registry System
1H-Imidazole-1-ethanol, ?-(2,4-dichlorophenyl)- (24155-42-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
38-28B-36-26
WGK Germany 
3
RTECS 
NI5485000
HS Code 
2933290000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000137
Product name
Enilconazole impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2231
Product name
Econazole Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100MG
Price
$522.5
Updated
2025/07/31
Sigma-Aldrich
Product number
CDS003858
Product name
1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol
Purity
AldrichCPR
Packaging
250mg
Price
$73.1
Updated
2025/07/31
Sigma-Aldrich
Product number
BP884
Product name
Miconazole impurity A
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$234
Updated
2025/07/31
Sigma-Aldrich
Product number
1231830
Product name
Enilconazole impurity E
Packaging
15mg
Price
$1300
Updated
2025/07/31
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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Chemical Properties,Usage,Production

Chemical Properties

cream-coloured to beige powder

Uses

Intermediate in the preparation of Miconazole. An impurity in the synthesis of Fenticonazole. An impurity in the synthesis of Ketoconazole.

Uses

Intermediate in the preparation of Miconazole.An impurity in the synthesis of Fenticonazole.An impurity in the synthesis of Ketoconazole.Econazole EP Impurity A.

Flammability and Explosibility

Not classified

Synthesis

46503-52-0

24155-42-8

General procedure for the synthesis of alpha-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol from 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone: In a 1000 mL three-necked flask equipped with a stirrer, a thermometer, and a dropping funnel, add 102 g of 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone (0.4 mol) and 300 mL of methanol. Potassium borohydride was added in batches and slowly heated to reflux. After completion of the reaction, stirring was continued for 1 h and the progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent was ethyl acetate: methanol = 10:1, v/v). At the end of the reaction, methanol was recovered by distillation under reduced pressure. The concentrate was adjusted to pH 4-5 with 5% hydrochloric acid solution and subsequently diafiltrated. The filtrate was adjusted pH to 7-8 with 5% sodium bicarbonate solution, when a white solid precipitated. The solid was collected by filtration, washed with water, dried and recrystallized to give 93.1 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol in 90.5% yield with a melting point of 134-135 °C.

References

[1] Patent: CN102180835, 2016, B. Location in patent: Paragraph 0015; 0016
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674
[3] Polyhedron, 2013, vol. 52, p. 106 - 114
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294
[5] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 162 - 175

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

Imazalil
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View Lastest Price from alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 24155-42-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Wuhan Biocar Pharmacy CO.,Ltd.
Product
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 24155-42-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
600kg
Release date
2025-03-26
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
1-(2,4dichlorophenyl) -2-(1H-imidazol-1-yl) Ethanol 24155-42-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kgs
Release date
2024-06-03

24155-42-8, alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanolRelated Search:

Monoethanolamine Imidazole Diethanolamine Dichlorodiphenylsilane Ethanol Levamisole Econazole Isoconazole Dichloroethane Ethyl acetate Diethylstilbestrol Dichloromethylphenylsilane 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE ALPHA-(CHLOROMETHYL)-2,4-DICHLOROBENZYL ALCOHOL Miconazole nitrate 2,4-Dichloro-β-[(2,6-dichlorophenyl)methoxy]benzeneethanamine Miconazole Impurity Miconazole IMpurity I

  • -(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
  • 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANOL
  • 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol
  • 1-(2,4-DICHLOROPHENYL)-2-IMIDAZOL-1-YL ETHANOL
  • 1H-IMIDAZOLE-1-ETHANOL, ALPHA-(2,4-DICHLOROPHENYL)-
  • ALPHA-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL
  • ALPHA-(2,4-DICHLOROPHENYL)-2-1H-IMIDAZOLE-1-ETHANOL
  • ALPHA-(2,4-DICHLORO PHENYL)-B-(IMIDAZOLE-YL)ETHANOL
  • 1-[2-(2,4-DichL
  • 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]-1H-imidazole, 2,4-Dichloro-alpha-[(1H-imidazol-1-yl)methyl]benzyl alcohol
  • 1-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-yl)-ethano
  • 1-(2,4-dichloro-phenyl)-2(Midazole-l-)-ethand
  • Isoconazole IMpurity A
  • 2,4-dichloro-alpha-(1-imidazolylmethyl)-benzylalcoho
  • alpha-(2,4-dichlorophenyl)-imidazole-1-ethano
  • n-(beta-(2,4-dichlorophenyl)-beta-hydroxyethyl)imidazole
  • r14821
  • t824
  • α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol ,99%
  • (1RS)-1-(2,4-Dichlorophenyl)-2-(-1H-imidazol-1-yl)ethanol
  • Isoconazole Nitrate EP Impurity A
  • Fenticonazole Nitrate impurity A (EP) -E
  • Fenticonazole Nitrate impurity A (EP)
  • Isoconazole EP impurity B
  • Imidazole alcohol
  • Econazole Impurity 1(Econazole EP Impurity A)
  • Miconazole Impurity 1(Miconazole EP Impurity A)
  • Fenticonazole Nitrate EP Impurity A
  • Econazole EP Impurity A
  • Miconazole EP Impurity A
  • Miconazole Nitrate EP Impurity A
  • 1-(2,4-Dichlorphenyl)-2-1-Imidazolyl)-Ethanol
  • 1-(2,4-Dichlorophenyl)-2-((1H)-imidazol-1-yl)-ethane
  • alpha-(2,4-Dichlorophenyl)-1H-
  • 2-(2,4-dichlorobenzene)-imidazole-1-ethanol
  • ALPHA- (2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-ETHANOL
  • IMIDAZOLE ETHANOL
  • Imidazole-1-ethanol alpha-(2,4-dichlorophenyl)
  • 1-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-1H-imidazole
  • 2,4-dichloro-alpha-(1-imidazolylmethyl)-benzyl alcohol
  • alpha-(2,4-dichlorophenyl)-imidazole-1-ethanol
  • 1H-IMIDAZOLE-1-ETHANOL,A-(2,4-DICHLOROPHENYL)-
  • 1,2(2,4-Dichlorophenyl)-1H-(N-Imidazolyl)Ethanol
  • A-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOLMICONAZOLE
  • 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
  • 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]imidazole
  • 1-(β-Hydroxy-2,4-dichlorophenethyl)-1H-imidazole
  • SQ-13283
  • alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol,98%
  • rac-1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol
  • Benzyl alcohol, 2,4-dichloro-alpha-(1-imidazolylmethyl)
  • （2，4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
  • Fenticonazole EP Impurity A
  • Isoconazole EP Impurity A
  • 1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol&gt
  • Sertaconazole nitrate EP Impurity A
  • (1RS)-1-(2,4-Dichlorophenyl)-2-(1H-
  • Enilconazole impurity E CRS