Description References
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Imazalil

Description References
Product Name
Imazalil
CAS No.
35554-44-0
Chemical Name
Imazalil
Synonyms
ENILCONAZOLE;Eniloconazol;ENICONAZOLE;chloramizole;1-[2-(2,4-dichlorophenyl)-2-prop-2-enoxyethyl]imidazole;MAZAL;r23979;Magnate;R 23979;FLO-PRO
CBNumber
CB4251497
Molecular Formula
C14H14Cl2N2O
Formula Weight
297.18
MOL File
35554-44-0.mol
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Imazalil Property

Melting point:
52.7°C
Boiling point:
>340°C
Density 
1.348
vapor pressure 
1.58 x l0-4 Pa (20 °C)
refractive index 
1.5680 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform: Slightly Soluble; Methanol: Slightly Soluble
pka
6.53 (weak base)
form 
Solid
color 
Light yellow to yellow
Water Solubility 
0.018 g/100 mL
Merck 
13,3616
BRN 
545683
InChIKey
PZBPKYOVPCNPJY-UHFFFAOYSA-N
LogP
3.820
CAS DataBase Reference
35554-44-0(CAS DataBase Reference)
NIST Chemistry Reference
Imazalil(35554-44-0)
EPA Substance Registry System
Imazalil (35554-44-0)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
20/22-41-50/53
Safety Statements 
26-39-60-61
RIDADR 
2588
WGK Germany 
3
RTECS 
NI4776000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29332900
Hazardous Substances Data
35554-44-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H332Harmful if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000136
Product name
Enilconazole
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000136
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
32007
Product name
Imazalil
Purity
PESTANAL
Packaging
100mg
Price
$83.9
Updated
2024/03/01
Cayman Chemical
Product number
25815
Product name
Imazalil
Packaging
50mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25815
Product name
Imazalil
Packaging
100mg
Price
$74
Updated
2024/03/01
TRC
Product number
I268503
Product name
Imazalil
Packaging
10g
Price
$110
Updated
2021/12/16
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Imazalil Chemical Properties,Usage,Production

Description

Imazalil (also known as Enilconazole) is a kind of topical mycotic agent that used for the treatment of fungi infections. It is primarily used for the treatment of fungi attracted to tubers of the crops, including Fusarium spp, Phoma spp, and Helminthosporum solani which reduces the crop quality. It can also be applied to citrus fruits. In addition, it can also be used for the treatment of Microsporum spp and Aspergillus spp infections occurring in the dogs, either as a single topic agent or being combined with oral administrated itraconazole or griseofulvin. The mechanism of action of Imazalil is through suppressing the biosynthesis pathway of ergosterol through blocking the demethylation process. 

References

http://www.vetbook.org/wiki/dog/index.php?title=Enilconazole
https://en.wikipedia.org/wiki/Enilconazole
https://www.mysciencework.com/publication/show/f0382c741754e9200388abe8cf2f0133

Description


Description

Imazalil is an imidazole fungicide that inhibits ergosterol biosynthesis. Imazalil inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7). It inhibits S. cerevisiae, but not rat liver microsomal, cytochrome P450 enzymes (CYPs; IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM). Imazalil activates the murine pregnane X receptor (PXR) in a concentration-dependent manner in a cell-based reporter assay. It increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice when administered at a dose of 100 mg/kg. Imazalil also increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the murine constitutive androstane receptor (mCAR) agonist TCPOBOP . Formulations containing imazalil have been used to control fungal infection in agriculture.

Uses

antifungal

Uses

As a disinfectant for stable and kennel equipment; experimentaly as an agricultural fungicide.

Uses

Imazalil is a systemic fungicide with protective and curative action. It is used for the control of a wide range of fungal diseases on fruit, vegetables and ornamentals, powdery mildew on roses and storage diseases of citrus fruit, pome fruit, bananas and seed potatoes. It is also used as a seed dressing, for control of diseases of cereals (particularly Fusarium and Helminthosporium spp.), and it is particularly active against benzimidazole-resistant strains of plant-pathogenic fungi.

Definition

ChEBI: 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole is a member of the class of imidazoles in which the hydrogen at position 1 is replaced by a 2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl group. It is a member of imidazoles, an ether and a dichlorobenzene.

General Description

Slightly yellow to brown solidified oil. Non-corrosive. Used as a fungicide.

Air & Water Reactions

Water soluble.

Reactivity Profile

Imazalil is an imidazole derivative.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. A skin and eye irritant. When heated to decomposition it emits toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Although no dosage forms are currently commercially available for topical use in the USA, Enilconazole is used topically for treating dermatophytosis in small animals and horses using compounded products. A commercially available topical rinse Imaverol? (Janssen) 10% is available with canine, bovine and equine use labeling in many countries. Intranasal instillation of enilconazole after plaque debridement has also been shown useful in treating nasal aspergillosis in small animals.
Use of topical enilconazole on cats with dermatophytosis is somewhat controversial as there are apparently no products with feline labeling available in Europe or Canada. There are preliminary reports of safely and successfully using enilconazole on dermatophytic cats in combination with oral itraconazole.
A topical product and a poultry environmental disinfectant product (Clinafarm EC?) is available in the USA. It is technically illegal to use this product other than it is labeled; it is an EPA licensed product in the USA.

Metabolic pathway

Published information is available on the metabolism of imazalil in plants and soils. The principal metabolite in plants and soils is 1-[2-(2,4- dichlorophenyl)-2-hydroxyethyl]-1H-imidazole.

Degradation

Imazalil is very stable to hydrolysis in dilute acids and alkalis at room temperature, in the absence of light. It is also stable to light under normal storage conditions.

Imazalil Preparation Products And Raw materials

Raw materials

Aluminium isopropoxide alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 2,4-Dichlorobenzyl alcohol Sodium borohydride Chloroacetyl chloride Aluminum chloride Imidazole Nitric acid Methanol Dilute hydrochloric acid 1,3-Dichlorobenzene Imazalil nitrate Allyl chloride

Preparation Products

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Imazalil Suppliers

China 251 Europe 1 France 3 Germany 2 India 2 Japan 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 22 USA 1 Global 286
Yifan biotechnology group co. LTD
Tel
0577-86637855
Fax
0577-86636638
Email
yifan@chinayifan.com
Country
CHINA
ProdList
1
Advantage
58
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Hunan Revel Biotechnology Co. , Ltd.
Tel
19359985961 19359985961
Email
2430503320@qq.com
Country
China
ProdList
1469
Advantage
58
Klong Industrial Co., Ltd
Tel
519-68231162 13961227312
Fax
0519-68231162
Email
info@klongchem.com
Country
China
ProdList
158
Advantage
58
Wuhan Biocar Pharmacy CO.,Ltd.
Tel
86-027-86589876 15377519203
Fax
16719025651
Email
2094286327@qq.com
Country
China
ProdList
498
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
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View Lastest Price from Imazalil manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Imazalil 35554-44-0
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-31
Baoji Guokang Bio-Technology Co., Ltd.
Product
Imazalil 35554-44-0
Price
US $62.00/KG
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
2000T
Release date
2021-06-04
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Imazalil 35554-44-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kgs
Release date
2024-06-03

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