(+)-EPIBATIDINE DIHYDROCHLORIDE
- Product Name
- (+)-EPIBATIDINE DIHYDROCHLORIDE
- CAS No.
- 148152-66-3
- Chemical Name
- (+)-EPIBATIDINE DIHYDROCHLORIDE
- Synonyms
- CMI 545;(±)Epibatidine,(±) Epibatidine;(+/-)-EPIBATIDINE HYDROCHLORIDE;(+)-EPIBATIDINE DIHYDROCHLORIDE;2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel-;(+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO-;EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE
- CBNumber
- CB3795844
- Molecular Formula
- C11H13ClN2
- Formula Weight
- 208.69
- MOL File
- 148152-66-3.mol
(+)-EPIBATIDINE DIHYDROCHLORIDE Property
- Boiling point:
- 336.7±32.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; <24.55mg/ml in ethanol
- form
- solid
- pka
- 10.07±0.40(Predicted)
- color
- Off White
- Water Solubility
- Soluble to 5 mM in water and to 100 mM in ethanol
N-Bromosuccinimide Price
- Product number
- E582200
- Product name
- (±)-Epibatidine
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- E582200
- Product name
- (±)-Epibatidine
- Packaging
- 5mg
- Price
- $430
- Updated
- 2021/12/16
- Product number
- E582200
- Product name
- (±)-Epibatidine
- Packaging
- 25mg
- Price
- $1540
- Updated
- 2021/12/16
- Product number
- B6406
- Product name
- (±)-Epibatidine
- Packaging
- 10mg
- Price
- $448
- Updated
- 2021/12/16
(+)-EPIBATIDINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
(-)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors.
Definition
ChEBI: 3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane is an alkaloid.
Biological Activity
(+)-aj 76 hydrochloride is an antagonist of dopamine autoreceptor with pki values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hd3, hd4, hd2s, hd2l and rd2 receptors, respectively.dopamine receptor is a g protein-coupled receptor and mainly exists in the vertebrate central nervous system (cns). dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control.(+)-aj 76 hydrochloride is a dopamine receptor antagonist. in rats, aj76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (dopac) and hva in brain, which were dopamine metabolites [1]. in rats injected with cocaine, (+)-a j76 increased the locomotor stimulation during the first 30 min. however, (+)-aj76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies [2]. in vivo, (+)-aj76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the a9 and a10 dopaminergic fibers. however, (+)-aj76 increased the level of dopac via the somatodendritic autoreceptors [3].
storage
Desiccate at +4°C
References
[1]. kullingsjö h, carlsson a, svensson k. effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-aj76, on locomotor activity and brain da metabolism in the rat. eur j pharmacol, 1991, 205(3): 241-246.
[2]. piercey mf, lum jt, hoffmann we, et al. antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-aj76 and (+)-uh232. brain res, 1992; 588(2): 217-222.
[3]. waters n, hansson l, löfberg l, et al. intracerebral infusion of (+)-aj76 and (+)-uh232: effects on dopamine release and metabolism in vivo. eur j pharmacol, 1994, 251(2-3): 181-190.
(+)-EPIBATIDINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-EPIBATIDINE DIHYDROCHLORIDE Suppliers
- Tel
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- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from (+)-EPIBATIDINE DIHYDROCHLORIDE manufacturers
- Product
- (+)-EPIBATIDINE DIHYDROCHLORIDE 148152-66-3
- Price
- US $8.00-0.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08