Ganitumab

Product Name: Ganitumab
CAS No.: 905703-97-1
Chemical Name: Ganitumab
Synonyms: AMG 479;Ganitumab;Ganitumab 4.92mg/ml;Ganitumab (anti-IGF1R);Research Grade Ganitumab;Research Grade Ganitumab (DHC29902)
CBNumber: CB38080757
Formula Weight: 0
MOL File: Mol file

More

Less

Ganitumab Property

form: Liquid
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Ganitumab Chemical Properties,Usage,Production

Uses

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].

in vivo

Ganitumab (AMG 479; 1 mg/dose; i.p; Na?ve and tumor-bearing mice) inhibits IGF1-induced activation of mIGF1R in murine lungs^[1].
Ganitumab (300 μg/dose; i.p.; female athymic nude mice) reduces peripheral blood neutrophils^[1].
Ganitumab (300 μg/dose; i.p.; male athymic nude mice) causes impaired glucose tolerance in male mice and increases serum levels of mGH, mIGF1 and mIGFBP3^[1].

Animal Model:	Na?ve and tumor-bearing mice^[1]
Dosage:	1 mg/dose
Administration:	Intraperitoneal injection
Result:	Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.

Animal Model:	Male athymic nude mice^[1]
Dosage:	300 μg/dose
Administration:	Intraperitoneal injection, twice per week for a total of five doses
Result:	Had significantly higher serum glucose levels than hIgG1-pretreated mice. Increased serum levels of mIGF1, mIGFPB3 and mGH.

Animal Model:	Female athymic nude mice^[1]
Dosage:	300 μg/dose
Administration:	Intraperitoneal injection, twice per week for a total of five doses
Result:	Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.

References

[1] Moody G, et, al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221(1):145-55. DOI:10.1530/JOE-13-0306

Ganitumab Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ganitumab Suppliers

China 18 United States 1 Global 19

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Country: China
ProdList: 544
Advantage: 58

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10308
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com
Country: China
ProdList: 9868
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6762
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

Wanxin Biotechnology (Jiaxing) Co., LTD

Tel: 0573-83568680 18057391398
Email: 3956524501@qq.com
Country: China
ProdList: 1442
Advantage: 58

Atagenix Laboratories

Tel: 027-87008169 17762441161
Email: info@atagenix.com
Country: China
ProdList: 10001
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

AntibodySystem Laboratories SAS

Tel: 33175446423
Email: support@antibodysystem.com
Country: China
ProdList: 6739
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Cell Sciences

Tel: 9785721070
Email: info@cellsciences.com
Country: China
ProdList: 6308
Advantage: 58

Guangzhou Chuangze Biotechnology Co., Ltd.

Tel: 18312220236
Country: CHINA
ProdList: 178
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

905703-97-1, GanitumabRelated Search:

Girentuximab Fremanezumab Ziltivekimab Naxitamab Aducanumab VEGFR2 Kinase Inhibitor I Emapalumab Zolbetuximab Tovetumab Mupadolimab

Ganitumab

Research Grade Ganitumab (DHC29902)

AMG 479

Research Grade Ganitumab

Ganitumab (anti-IGF1R)

Ganitumab 4.92mg/ml

905703-97-1