Plamotamab

Product Name: Plamotamab
CAS No.: 2138442-31-4
Chemical Name: Plamotamab
Synonyms: Plamotamab;Research Grade Plamotamab
CBNumber: CB38081143
Formula Weight: 0
MOL File: Mol file

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Plamotamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Plamotamab Chemical Properties,Usage,Production

Uses

Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20+ expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo[1][2].

in vivo

Plamotamab (0.17 mg/kg; i.p.) causes tumor growth suppression in human PBMC-engrafted mouse model containing Raji xenograft^[2].
Plamotamab (0.3 mg/kg; i.p.) leads to cytokine release in cynomolgus monkeys, indicating a safety to be improved^[2].

References

[1] Parrondo RD, et al. Plamotamab (XmAb?13676) for Ibrutinib- refractory CXCR4-mutated extramedullary Waldenstr?m macroglobulinemia. Leuk Lymphoma. 2022 Mar;63(3):738-742. DOI:10.1080/10428194.2021.2005045
[2] Luo Peter PZ, et al. Anti-CD3 antibodies and methods of use thereof. World Intellectual Property Organization, WO2022170740 A1. 2022-08-18.

Plamotamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Plamotamab Suppliers

China 10 Global 10

ShangHai Biochempartner Co.,Ltd

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Cell Sciences

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Guangzhou Chuangze Biotechnology Co., Ltd.

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2138442-31-4, PlamotamabRelated Search:

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Plamotamab

Research Grade Plamotamab

2138442-31-4