Navicixizumab

Product Name: Navicixizumab
CAS No.: 1638338-43-8
Chemical Name: Navicixizumab
Synonyms: Navicixizumab;Navicixizumab (anti-DLL4);Research Grade Navicixizumab;Research Grade Navicixizumab (DHJ65303)
CBNumber: CB88080974
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Navicixizumab Chemical Properties,Usage,Production

Uses

Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel.html" class="link-product" target="_blank"> Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer[1][2][3].

in vivo

Navicixizumab (15 mg/kg, once a week for 4 weeks) inhibits colon xenograft tumor growth^[3].

References

[1] Fu S, et al. Phase Ib Study of Navicixizumab Plus Paclitaxel in Patients With Platinum-Resistant Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. J Clin Oncol. 2022 Aug 10;40(23):2568-2577. DOI:10.1200/JCO.21.01801
[2] Perez-Fidalgo JA, et al. NOTCH signalling in ovarian cancer angiogenesis. Ann Transl Med. 2020 Dec;8(24):1705. DOI:10.21037/atm-20-4497
[3] Wan-Ching Yen, et al. Abstract C164: Dual targeting of the DLL4 and VEGF pathways with a bispecific monoclonal antibody inhibits tumor growth and reduces cancer stem cell frequency. Mol Cancer Ther (2015) 14 (12_Supplement_2): C164.

Navicixizumab Preparation Products And Raw materials

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Preparation Products

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Navicixizumab Suppliers

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1638338-43-8, NavicixizumabRelated Search:

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Navicixizumab

Research Grade Navicixizumab (DHJ65303)

Research Grade Navicixizumab

Navicixizumab (anti-DLL4)

1638338-43-8