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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE

Product Name
METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
CAS No.
623583-88-0
Chemical Name
METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
Synonyms
methyl 2-bromoquinoline-6-carboxylate;METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE;6-Bromo-quinoline-2-carboxylic acid methyl ester;2-Quinolinecarboxylic acid, 6-bromo-, methyl ester
CBNumber
CB3814044
Molecular Formula
C11H8BrNO2
Formula Weight
266.09
MOL File
623583-88-0.mol
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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Property

Boiling point:
374.6±22.0 °C(Predicted)
Density 
1.557±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
1.18±0.43(Predicted)
Appearance
Off-white to pink Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0356046
Product name
METHYL-6-BROMOQUINOLINE-2-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$505.92
Updated
2021/12/16
AK Scientific
Product number
4318AJ
Product name
Methyl6-bromoquinoline-2-carboxylate
Packaging
5g
Price
$2397
Updated
2021/12/16
J&W Pharmlab
Product number
80R0245
Product name
6-Bromo-quinoline-2-carboxylicacidmethylester
Purity
97%
Packaging
100mg
Price
$125
Updated
2021/12/16
Chemenu
Product number
CM123373
Product name
methyl6-bromoquinoline-2-carboxylate
Purity
97%
Packaging
1g
Price
$306
Updated
2021/12/16
Crysdot
Product number
CD11087141
Product name
Methyl6-bromoquinoline-2-carboxylate
Purity
97%
Packaging
1g
Price
$324
Updated
2021/12/16
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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

67-56-1

65148-10-9

623583-88-0

1c) Synthesis of methyl 6-bromo-2-quinolinecarboxylate A mixture of 6-bromo-2-quinolinecarboxylic acid (331 g, multiple batches, 1.31 mol) and methanesulfonic acid (22 mL, 33 g, 0.34 mol) in methanol (2 L) was refluxed for 6 hours. Upon completion of the reaction, the reaction mixture was neutralized with an aqueous solution of sodium bicarbonate (29 g, 0.34 mol) (350 mL). The resulting suspension was slowly cooled to 20 °C and stirred continuously overnight. The solid product was collected by filtration and the filter cake was washed with water (1 L). The solid product was dried in a vacuum oven at 50 °C for 3 days to give methyl 6-bromo-2-quinolinecarboxylate (294 g, 85% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (d, J = 9 Hz, 1H), 8.40 (d, J = 2 Hz, 1H), 8.14 (d, J = 9 Hz, 1H), 8.08 (d, J = 9 Hz, 1H), 7.97 (m, 1H), 3.93 (s, 3H). ES-LCMS m/z 267 (M + H)+.

References

[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 32
[2] Tetrahedron, 2014, vol. 70, # 42, p. 7686 - 7690
[3] Patent: WO2011/127643, 2011, A1. Location in patent: Page/Page column 38

METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Suppliers

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623583-88-0, METHYL 6-BROMOQUINOLINE-2-CARBOXYLATERelated Search:

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  • METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
  • 6-Bromo-quinoline-2-carboxylic acid methyl ester
  • 2-Quinolinecarboxylic acid, 6-bromo-, methyl ester
  • methyl 2-bromoquinoline-6-carboxylate
  • 623583-88-0