METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE

Product Name: METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
CAS No.: 623583-88-0
Chemical Name: METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
Synonyms: methyl 2-bromoquinoline-6-carboxylate;METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE;6-Bromo-quinoline-2-carboxylic acid methyl ester;2-Quinolinecarboxylic acid, 6-bromo-, methyl ester
CBNumber: CB3814044
Molecular Formula: C11H8BrNO2
Formula Weight: 266.09
MOL File: 623583-88-0.mol

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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Property

Boiling point:: 374.6±22.0 °C(Predicted)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.18±0.43(Predicted)
Appearance: Off-white to pink Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0356046
Product name: METHYL-6-BROMOQUINOLINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.92
Updated: 2021/12/16

AK Scientific

Product number: 4318AJ
Product name: Methyl6-bromoquinoline-2-carboxylate
Packaging: 5g
Price: $2397
Updated: 2021/12/16

J&W Pharmlab

Product number: 80R0245
Product name: 6-Bromo-quinoline-2-carboxylicacidmethylester
Purity: 97%
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Chemenu

Product number: CM123373
Product name: methyl6-bromoquinoline-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $306
Updated: 2021/12/16

Crysdot

Product number: CD11087141
Product name: Methyl6-bromoquinoline-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $324
Updated: 2021/12/16

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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

67-56-1

65148-10-9

623583-88-0

1c) Synthesis of methyl 6-bromo-2-quinolinecarboxylate A mixture of 6-bromo-2-quinolinecarboxylic acid (331 g, multiple batches, 1.31 mol) and methanesulfonic acid (22 mL, 33 g, 0.34 mol) in methanol (2 L) was refluxed for 6 hours. Upon completion of the reaction, the reaction mixture was neutralized with an aqueous solution of sodium bicarbonate (29 g, 0.34 mol) (350 mL). The resulting suspension was slowly cooled to 20 °C and stirred continuously overnight. The solid product was collected by filtration and the filter cake was washed with water (1 L). The solid product was dried in a vacuum oven at 50 °C for 3 days to give methyl 6-bromo-2-quinolinecarboxylate (294 g, 85% yield). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (d, J = 9 Hz, 1H), 8.40 (d, J = 2 Hz, 1H), 8.14 (d, J = 9 Hz, 1H), 8.08 (d, J = 9 Hz, 1H), 7.97 (m, 1H), 3.93 (s, 3H). ES-LCMS m/z 267 (M + H)+.

References

[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 32
[2] Tetrahedron, 2014, vol. 70, # 42, p. 7686 - 7690
[3] Patent: WO2011/127643, 2011, A1. Location in patent: Page/Page column 38

METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE Suppliers

China 35 India 1 United States 4 Global 40

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Amadis Chemical Company Limited

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Sichuan BaiPeng Biotechnology Co., Ltd.

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Capot Chemical Co.,Ltd.

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623583-88-0, METHYL 6-BROMOQUINOLINE-2-CARBOXYLATERelated Search:

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METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE

6-Bromo-quinoline-2-carboxylic acid methyl ester

2-Quinolinecarboxylic acid, 6-bromo-, methyl ester

methyl 2-bromoquinoline-6-carboxylate

623583-88-0