ChemicalBook > CAS DataBase List > 1-(2-Furoyl)piperazine

1-(2-Furoyl)piperazine

Product Name
1-(2-Furoyl)piperazine
CAS No.
40172-95-0
Chemical Name
1-(2-Furoyl)piperazine
Synonyms
AKOS BB/0087;AKOS B003992;AKOS BBS-00003689;BIO-FARMA BF003584;TIMTEC-BB SBB003747;RARECHEM AH CK 0108;N-Furoyl piperazine;2-furoic piperazide;Terazosin Impurity10;2-(2-FUROYL)PIPERAZINE
CBNumber
CB3853599
Molecular Formula
C9H12N2O2
Formula Weight
180.2
MOL File
40172-95-0.mol
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1-(2-Furoyl)piperazine Property

Melting point:
67-70 °C(lit.)
Boiling point:
137-140°C 0,1mm
Density 
1.1819 (rough estimate)
refractive index 
1.5373 (estimate)
Flash point:
>230 °F
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform, Methanol (Slightly)
pka
8.37±0.10(Predicted)
color 
White to Pale Yellow
Sensitive 
Hygroscopic
BRN 
880196
Stability:
Very Hygroscopic
CAS DataBase Reference
40172-95-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
F 
10-34
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3100
Product name
Prazosin Related Compound D
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
558966
Product name
1-(2-Furoyl)piperazine
Purity
97%
Packaging
25g
Price
$133
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0000623
Product name
Terazosin impurity L
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000623
Price
$149
Updated
2023/01/07
Alfa Aesar
Product number
A16773
Product name
1-(2-Furoyl)piperazine, 98%
Packaging
25g
Price
$65.5
Updated
2021/12/16
Alfa Aesar
Product number
A16773
Product name
1-(2-Furoyl)piperazine, 98%
Packaging
100g
Price
$188
Updated
2021/12/16
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1-(2-Furoyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow solid

Uses

2-Furanyl-1-piperazinylmethanone (Terazosin EP Impurity L) was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Uses

1-(2-Furoyl)piperazine may be used to synthesize:

  • 2-[4-(2-furoyl) piperazin-1-yl]-4-amino-6-benzyloxy-7-methoxyquinazoline hydrochloride monohydrate
  • 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-7-benzyloxy-6-methoxyquinazoline hydrochloride monohydrate
  • 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-quinazoline hydrochloride
  • 6,7-dimethoxy-2-[4-(2-furoyl)-piperazin-1-yl]quinazoline-4-one hydrate
  • 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-furoyl)-piperazine hydrogen oxalate
  • 1-(3,4-dichlorobenzyl)-4-(2-furoyl)-piperazine hydrogen oxalate
  • 4-(9-fluorenyl)-1-(2-furoyl)piperazine
  • 2-[4-(2-furoyl)piperazin-1-yl]-benzimidazole hydrochloride hydrate

Uses

2-Furanyl-1-piperazinylmethanone was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 146, 1977 DOI: 10.1021/jm00211a031

1-(2-Furoyl)piperazine Preparation Products And Raw materials

Raw materials

2-Furoic acid Toluene Di-tert-butyl dicarbonate Triethylamine Piperazine Dichloromethane Sodium hydroxide Thionyl chloride

Preparation Products

Prazosin
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View Lastest Price from 1-(2-Furoyl)piperazine manufacturers

Career Henan Chemical Co
Product
1-(2-Furoyl)piperazine 40172-95-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2019-08-30

40172-95-0, 1-(2-Furoyl)piperazineRelated Search:

N-Aminoethylpiperazine 2-Ethylhexyl ferulate Piperazine Piperacillin 1-(Tetrahydro-2-Furoyl)Piperazine,TerazosinHcl,,1-(TETRAHYDRO-2-FUROYL)PIPERAZINE,N-(TETRAHYDRO-2-FUROYL)-PIPERAZINE 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride Terazosin impurity 2-Piperazine-4-amino-6,7-dimethoxyquinazoline (R)-Terazosin 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine] 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one Terazosin EP IMpurity D [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone NSC 351869 [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl][(5S)-tetrahydro-5-Methyl-2-furanyl]Methanone Terazosin hydrochloride dihydrate Terazosin IMpurity J

  • BIO-FARMA BF003584
  • (FURAN-2-YL)(PIPERAZIN-1-YL)METHANONE
  • 1-(2-FURANYLCARBONYL)-PIPERAZINE
  • 1-(2-FUROYL)PIPERAZINE
  • AKOS BBS-00003689
  • AKOS B003992
  • AKOS BB/0087
  • N-(2-FUROYL)PIPERAZINE
  • RARECHEM AH CK 0108
  • TIMTEC-BB SBB003747
  • 2-(2-FUROYL)PIPERAZINE
  • N-Furoyl piperazine
  • 1-(2-FUROYL)-PIPERAZINE 97%
  • 2-furoic piperazide
  • 1-(2-Furoyl)piperazine,98%
  • Piperazine, 1-(2-furanylcarbonyl)-
  • (2-Furyl)(piperazino) ketone
  • Piperazino 2-furyl ketone
  • Piperazino(2-furanyl) ketone
  • Piperazino(2-furyl) ketone
  • 1-(2-Furoyl)-piperazine ,97%
  • Prazosin EP IMpurity D
  • 2-Furanyl-1-piperazinylmethanone
  • 1-(2-Furoyl)piperazine96%
  • N-(2-Furoyl) piperazine 1-(2-Furoyl) piperazine
  • Terazosin EP Impurity L
  • Terazosin Impurity 12(Terazosin EP Impurity L)
  • Terazosin Impurity10
  • Prazosin Impurity 4(Prazosin EP Impurity D)
  • 1-(furan-2-carbonyl)piperazine
  • Terazosin EP Impurity L (Prazosin EP Impurity D)
  • Prazosin EP Impurity D (Terazosin EP Impurity L)
  • Methanone, 2-furanyl-1-piperazinyl-
  • 40172-95-0 1-(2-Furoyl)piperazine
  • Prazosin Hydrochloride Impurity D
  • Terazosin Hydrochloride Dihydrate Impurity L
  • Terazosin Hydrochloride Dihydrate EP Impurity L
  • 40172-95-0
  • Heterocyclic Building Blocks
  • Piperazines
  • Building Blocks
  • BUILDING BLOCKS
  • API intermediates
  • Piperidines, Piperidones, Piperazines