1-(2-Furoyl)piperazine Property

Melting point:

67-70 °C(lit.)

Boiling point:

137-140°C 0,1mm

Density 

1.1819 (rough estimate)

refractive index 

1.5373 (estimate)

Flash point:

>230 °F

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform, Methanol (Slightly)

pka

8.37±0.10(Predicted)

color 

White to Pale Yellow

Sensitive 

Hygroscopic

BRN 

880196

Stability:

Very Hygroscopic

CAS DataBase Reference

40172-95-0(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

F 

10-34

HazardClass 

IRRITANT

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-(2-Furoyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow solid

Uses

2-Furanyl-1-piperazinylmethanone (Terazosin EP Impurity L) was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Uses

1-(2-Furoyl)piperazine may be used to synthesize:

• 2-[4-(2-furoyl) piperazin-1-yl]-4-amino-6-benzyloxy-7-methoxyquinazoline hydrochloride monohydrate
• 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-7-benzyloxy-6-methoxyquinazoline hydrochloride monohydrate
• 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-quinazoline hydrochloride
• 6,7-dimethoxy-2-[4-(2-furoyl)-piperazin-1-yl]quinazoline-4-one hydrate
• 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-furoyl)-piperazine hydrogen oxalate
• 1-(3,4-dichlorobenzyl)-4-(2-furoyl)-piperazine hydrogen oxalate
• 4-(9-fluorenyl)-1-(2-furoyl)piperazine
• 2-[4-(2-furoyl)piperazin-1-yl]-benzimidazole hydrochloride hydrate

Uses

2-Furanyl-1-piperazinylmethanone was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 146, 1977 DOI: 10.1021/jm00211a031