Eletriptan hydrobromide

Product Name: Eletriptan hydrobromide
CAS No.: 177834-92-3
Chemical Name: Eletriptan hydrobromide
Synonyms: Relert;Uk 116044-04;Eletriptan HCl;ELETRIPTAN HBR;Eletriptan Base;Unii-m41W832ta3;Eletriptan-d3 HBr;QR-2008082103-ELCPT;etriptan hydrobromide;eletriptan hydrobromide
CBNumber: CB3854925
Molecular Formula: C22H27BrN2O2S
Formula Weight: 463.43
MOL File: 177834-92-3.mol

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Eletriptan hydrobromide Property

Melting point:: 169-171?C
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: >10mg/mL
form: powder
color: off-white to light tan
InChIKey: PWVXXGRKLHYWKM-IBGZPJMESA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3032
Product name: Eletriptan hydrobromide
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $94.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3032
Product name: Eletriptan hydrobromide
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $306
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1234453
Product name: Eletriptan Hydrobromide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200MG
Price: $715
Updated: 2024/03/01

TRC

Product number: R143400
Product name: Relpax
Packaging: 25mg
Price: $230
Updated: 2021/12/16

AK Scientific

Product number: J99624
Product name: Eletriptan hydrobromide
Packaging: 25mg
Price: $221
Updated: 2021/12/16

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Eletriptan hydrobromide Chemical Properties,Usage,Production

Chemical Properties

Eletriptan hydrobromide is Tan Solid

Originator

Relpax,Pfizer

Uses

Relpax is a second generation triptan drug used in the treatment of migraine headaches.

Uses

antibiotic

Uses

Eletriptan hydrobromide is a second generation triptan drug used in the treatment of migraine headaches.

Definition

ChEBI: Eletriptan hydrobromide is a hydrobromide. It has a role as a serotonergic agonist, a vasoconstrictor agent and a non-steroidal anti-inflammatory drug. It contains an eletriptan(1+).

Manufacturing Process

A mixture of the appropriate phenyl vinyl sulfone, tri-o-tolylphosphine, palladium (II) acetate, triethlamine and (R)-5-bromo-3-(Nmethylpyrrolidinylmethyl)-1H-indole in anhydrous acetonitrle was heated at reflux under nitrogen. The resultant reaction mixture was evaporated under reduced pressure, and the residue was column chromatographed using silica gel and elution with methylene chloride/absolute ethanol/ammonia to afford the (R )-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)- 1H-indole.
A solution of (R)-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2- ylmethyl)-1H-indole and 10% Pd/C in ethanolic hydrogen chloride (prepared from absolute ethanol and acetyl chloride and N,N-dimethylformamide was shaken under a hydrogen atmosphere at room temperature). The resultant reaction mixture was filtered through diatomaceous earth (Celite trademark), washed with absolute ethanol, and the combined filtrates were evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic phase was separated, washed with water, brine, dried(Na2SO4), and evaporated under reduced pressure to afford a oil product. Column chromatography of this product using silica gel and elution with methylene chloride/absolute ethanol/ammonia afforded the appropriate (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole.
The salt eletriptan hydrobromide may be produced by reaction of the (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole with hydrobromic acid.

brand name

Relpax (Pfizer).

Therapeutic Function

Serotonin agonist

Biological Activity

Orally active, selective 5-HT 1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo . Displays antimigraine activity.

storage

room temperature (desiccate)

Eletriptan hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Eletriptan hydrobromide Suppliers

Canada 1 China 155 Europe 2 France 1 India 25 Israel 1 Italy 1 United Kingdom 3 United States 21 Global 210

LGM Pharma

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TargetMol Chemicals Inc.

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View Lastest Price from Eletriptan hydrobromide manufacturers

Shijiazhuang tongyang Import and Export Co., LTD

Product: Eletriptan hydrobromide 177834-92-3
Price: US $10.00/KG
Min. Order: 1g
Purity: 99
Supply Ability: 2000kg
Release date: 2021-08-10

Cangzhou Wanyou New Material Technology Co.,Ltd

Product: Eletriptan hydrobromide 177834-92-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 8000 Kilogram/Kilograms per Month
Release date: 2019-04-23

Career Henan Chemical Co

Product: Eletriptan hydrobromide 177834-92-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

177834-92-3, Eletriptan hydrobromideRelated Search:

Bensulfuron methyl Thiophanate-methyl Eletriptan Scopolamine hydrobromide Hydrogen bromide METSULFURON METHYL Methylparaben Kresoxim-methyl Dextromethorphan hydrobromide monohydrate Methyl salicylate Methyl acetate Citalopram hydrobromide Zolmitriptan Galantamine Hydrobromide Tri(o-tolyl)phosphine Methyl Parathion-methyl DEXTROMETHORPHAN HYDROBROMIDE

Unii-m41W832ta3

Relpax Also see: E505000

Eletriptan HCl

1H-Indole,3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-,hydrobromide

(R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-Methylpyrrolidin-2-yl)Methyl]-1H-indole hydrobroMide

Relert

(R)-3-((1-Methylpyrrolidin-2-yl)Methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole hydrobroMide

eletriptan hydrobromide

3-(((2r)-1-methyl-2-pyrrolidinyl))methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole hydrobromide

ELETRIPTAN HBR

Eletriptan Base

1H-Indole, 3-(((2R)-1-methyl-2-pyrrolidinyl))methyl)-5-(2-(phenylsulfonyl)ethyl)-, monohydrobromide

Uk 116044-04

Eletriptan hydrobromide (Eletriptan HBr)

Eletriptan hydrobromide, 99%, a selective 5-HT1B/1D receptor agonist

5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole hydrobromide

Eletriptan-d3 HBr

etriptan hydrobromide

Eletriptan hydrobromide USP/EP/BP

QR-2008082103-ELCPT

Eletriptan Related compound 01

Eletriptan HydrobromideQ: What is Eletriptan Hydrobromide Q: What is the CAS Number of Eletriptan Hydrobromide Q: What is the storage condition of Eletriptan Hydrobromide Q: What are the applications of Eletriptan Hydrobromide

177834-92-3 Eletriptan hydrobromide

1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-, hydrobromide (1:1)

(R)-5-(2-Benzenesulfonyl -ethyl)-3-(1- methyl- pyrrolidin-2- ylmethyl)-1H- indole. Hydrobromide

177834-92-3

C22H26N2O2SHBr

C22H26N2O2SBrH

C22H27BrN2O2S

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pfizer compounds

Pharmaceuticals