tert-Butyl rosuvastatin

Product Name: tert-Butyl rosuvastatin
CAS No.: 355806-00-7
Chemical Name: tert-Butyl rosuvastatin
Synonyms: Rosuvastatin tert-butyl ester;Rosuvastatin t-Butyl Ester;tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoate;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester;ZD-8;R1.5;tert-Butyl rosuvasta;ert-Butylrosuvastatin;dihydroxyhept-6-enoate;tert-butyl rosuvastatin
CBNumber: CB3855018
Molecular Formula: C26H36FN3O6S
Formula Weight: 537.64
MOL File: 355806-00-7.mol

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tert-Butyl rosuvastatin Property

Melting point:: 136-138oC
Boiling point:: 704.2±70.0 °C(Predicted)
Density: 1.259
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
form: Solid
pka: 13.38±0.20(Predicted)
color: White to Off-White
optical activity: Consistent with structure
Stability:: Hygroscopic
InChIKey: IJHZGLLGELSZAF-OKLSWEBGSA-N
SMILES: C(OC(C)(C)C)(=O)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C1C1=CC=C(F)C=C1
CAS DataBase Reference: 355806-00-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: R700540
Product name: Rosuvastatintert-ButylEster
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Usbiological

Product number: 290783
Product name: Tert-Butyl Rosuvastatin
Packaging: 50g
Price: $545
Updated: 2021/12/16

AK Scientific

Product number: J11262
Product name: RosuvastatinImpurity20(tert-ButylRosuvastatin)
Packaging: 25mg
Price: $38
Updated: 2021/12/16

AK Scientific

Product number: N746
Product name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoicacidtert-butylester
Packaging: 1g
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: N746
Product name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoicacidtert-butylester
Packaging: 10g
Price: $190
Updated: 2021/12/16

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tert-Butyl rosuvastatin Chemical Properties,Usage,Production

Uses

Rosuvastatin tert-Butyl Ester, is a metabolite of Rosuvastatin (R700500) a selective, competitive HMG-CoA reductase inhibitor.

Uses

tert-Butyl Rosuvastatin is an impurity of Rosuvastatin (287714-41-4 #CAS), which is a HMG-?CoA reductase inhibitor. In combination of pemafibrate or a salt, it can function as cardiovascular disease medication.

Synthesis

To a 500 ml flask equipped with a nitrogen blower and a mechanical stirrer was added the precursor compound of unsaturated carbonyls (18.60 g), tetrahydrofuran (40.5 ml) and methanol (11.5 ml) and the resulting suspension was stirred at room temperature to give a clear solution. To a 1000 ml three-necked flask equipped with a mechanical stirrer and a nitrogen blower, tetrahydrofuran (232 ml) and methanol (66.5 ml) were added to form a mixture. NaBH4 (2.22 g, 2.7 eq.) was then added, Methoxy-9-BBN (24 mL, 1.1 eq.) was added, and the mixture was stirred at -78??C for 10 min, then the tetrahydrofuran solution of the precursor compounds described above was added dropwise to the Methoxy-9-BBN mixture over a period of 1.5 h, and the reaction mixture was further stirred at -78??C for for 1 hour. H2O2 (9.3 mL, 30%) was then added and the reaction mixture was allowed to come to room temperature. Ethyl acetate (58 mL) and NH4Cl (174 mL) were slowly added to the reaction mixture under stirring at room temperature, the two phases were separated and separated by filtration. The organic phase was washed with saturated Na2SO3 (solution 46 mL) followed by H2O (116 mL), NaCl (116 mL) and then the organic phase was evaporated to dryness to obtain the target product tert-butyl resuvastatin.

tert-Butyl rosuvastatin Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl rosuvastatin Suppliers

China 195 Germany 1 India 8 United Kingdom 2 United States 11 Global 217

Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.

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BOC Sciences

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View Lastest Price from tert-Butyl rosuvastatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: tert-Butyl rosuvastatin 355806-00-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kg
Release date: 2021-08-10

Hangzhou ICH Biofarm Co., Ltd

Product: tert-Butyl rosuvastatin 355806-00-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200
Release date: 2023-07-11

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: tert-Butyl rosuvastatin 355806-00-7
Price: US $5.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2021-12-23

355806-00-7, tert-Butyl rosuvastatinRelated Search:

2-Butoxyethanol Pravastatin Kresoxim-methyl Butyl acetate Isopropyl acetate Aminopyrine EC 2.6.1.2 Sulfamic acid Methyl acrylate Glucosamine ISOPROPYL LAURATE Rosuvastatin calcium Acetaminophen Simvastatin Methylparaben Atorvastatin Butyl acrylate Acetonitrile

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester

tert-butyl rosuvastatin

tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoate

(+)-(3R, 5S)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHANESULFONYLAMINO)PYRIMIDIN-5-YL]-(3, 5)-DIHYDROXY-6(E)-HEPTENOATE

Rosuvastatin intermediate R-3

tert-Butyl(+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methanesul fonylamino)pyrimidin-5-yl]-3,5-Dihydroxy-6(E)-Heptenoate

ZD-8

Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylamino)pyrimidine-5-yl] -(3R,5S) -dihydroxy -(E)-6-Heptena

Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dihydroxy

Rosuvastatin tert-butyl ester

(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)]-2-[Methyl(Methylsulfonyl)aMino-5-pyriMidinyl]-3,5-dihydroxy-6-heptenoicacidtert-butylester

T-BUTYL 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL] -(3R,5S)-DIHYDROXY-(E)-6-HEPTENATE

Rosuvastatin t-Butyl Ester

tert-Butyl rosuvasta

Rosuvastatin calciuM interMediate R-3

(3R,5S,6E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(METHANESULFONYL) METHYL AMINO]PYRIMIDIN-5-YL

Rosuvastatin Acid t-Butyl Ester

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]-pyrimidin-5-yl]-3,

tert-Butyl Rosuvastatin (Rosuvastatin IMpurity)

Rosuvastatin tert-butyl

(+)-(3r, 5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-6(E)-Heptenate (R1.5 Or T-Butyl-Rosuvastatin)

R-1.5: (+)-(3R, 5S), TERT-BUTYL 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYLSULPHONYLAMINO)-PYRIMIDINE-5-YL]-3, 5-DIHYDROXY-6(E)-HEPTENATE

(E) - (3R,5S)-7-{4-(4-FLUOROPHENYL)-6-ISOPROPYL-2{METHYL SULPHONYLAMINO)] PYRIMIDIN-5-YL}-3,5-DIHYDROXYHEPTEN6-6 OICACID

dihydroxyhept-6-enoate

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid t-butyl ester

tert-butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N- methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept- 6-enoate

Rosuvatatin Impurity 22

Rosuvastatin Impurity 77

Rosuvastatin calcium-001

Rosuvastatin calcium-001-3R5S

Rosuvastatin Impurity 20 (tert-Butyl Rosuvastatin)

Rosuvastatin Impurity 7/Rosuvastatin tert-Butyl Ester/(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]-pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester

Rosuvastatin calcium-11

R1.5

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E)-

ert-Butylrosuvastatin

tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5- dihydroxyhept-6-enoate(R2)

tert-Butyl rosuvastatin,(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl amino)pyrinidine-5-yl]-3,5-dihydrosy-6-heptane acid,Methyl ester

(+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-6(E)-Heptenate (R1.5 Or T-Butyl-Rosuvastatin)

(+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-...

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester

Rivastatin tert-butyl ester

Rosuvastatin calcium impurity 10

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2 [(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5 dihydroxyhept -6-enoic acid tert-butyl ester or (Tert Butyl Rosuvastatin)

tert-Butyl Rosuvastatir

Rosuvastatin EP Impurity 10

tert-butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoicacidtert-butylester

(6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoicacidtert-butylester

Rosuvatatin Tertiarybutyl Ester

355806-00-7

C26H36FN3O6S

Rosuvastatin intermediates

Rosuvastatin Calcium and its intermediates