(S)-4-(Phenylmethyl)-2-piperazineethanol

Product Name: (S)-4-(Phenylmethyl)-2-piperazineethanol
CAS No.: 477220-33-0
Chemical Name: (S)-4-(Phenylmethyl)-2-piperazineethanol
Synonyms: (S)-2-(4-benzylpiperazin-2-yl)ethanol;2-((S)-4-benzylpiperazin-2-yl)ethanol;(s)-4-(phenylmethyl)-2-piperazineethanol;(S)-2-(4-Benzylpiperazin-2-yl)ethan-1-ol;2-[(2S)-4-benzylpiperazin-2-yl]ethan-1-ol;(S)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl;2-Piperazineethanol, 4-(phenylmethyl)-, (2S)-
CBNumber: CB3855104
Molecular Formula: C13H20N2O
Formula Weight: 220.31
MOL File: 477220-33-0.mol

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(S)-4-(Phenylmethyl)-2-piperazineethanol Property

storage temp.: Store at Room Tem.
Appearance: light yellow powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0000498
Product name: 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0000498
Product name: 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL
Purity: 95.00%
Packaging: 5G
Price: $2708.48
Updated: 2021/12/16

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(S)-4-(Phenylmethyl)-2-piperazineethanol Chemical Properties,Usage,Production

Synthesis

612506-99-7

477220-33-0

General procedure for the synthesis of 2-[(S)-4-benzyl-2-yl]ethanol from the compound (CAS:612506-99-7): to a tetrahydrofuran (1L) solution of methyl S-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate (31.9 g, 0.12 mol) at 0 °C, lithium aluminum hydride (350 mL, 1.0 M tetrahydrofuran solution). The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction was quenched by successive careful addition of 13.3 mL of water, 13.3 mL of 15% aqueous sodium hydroxide solution and 39.9 mL of water, during which vigorous stirring was maintained to ensure the formation of a fine precipitate. The reaction mixture was filtered through a sintered funnel and the solid fraction was washed well with tetrahydrofuran and dichloromethane. The filtrate was concentrated under vacuum to give 26.5 g of an oily residue which was directly sampled on a silica gel column. Column chromatographic separation was carried out using a 5% 7N ammonia-methanol dichloromethane mixture as eluent to obtain the target product, which was an orange-colored oil and solidified to a solid after vacuum drying. This solid was dissolved in acetonitrile, sonicated for several minutes and filtered to give 7.5 g (25% yield) of S-(-)-2-(4-benzylpiperazin-2-yl)ethanol as an off-white crystalline solid with a melting point of 78.9-80 °C. The mother liquor was concentrated to give 6.8 g (23% yield) of a slightly less pure product as an amorphous solid.

References

[1] Patent: WO2003/82877, 2003, A1. Location in patent: Page/Page column 96-97
[2] Patent: WO2005/26177, 2005, A1. Location in patent: Page/Page column 91-92
[3] Patent: WO2004/14895, 2004, A1. Location in patent: Page 125-126

(S)-4-(Phenylmethyl)-2-piperazineethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-4-(Phenylmethyl)-2-piperazineethanol Suppliers

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477220-33-0