Ethyl 2-oxohexanoate
- Product Name
- Ethyl 2-oxohexanoate
- CAS No.
- 5753-96-8
- Chemical Name
- Ethyl 2-oxohexanoate
- Synonyms
- Ethyl 2-oxohexanoate;ethyl alpha-ketocaproate;2-ketoHexanoicacidethylester;2-Oxyhexanoic acid ethyl ester;2-Ketocaproic acid ethyl ester;2-oxohexanoic acid ethyl ester;Ethyl 2-oxohexanoate - [E12153];Hexanoic acid, 2-oxo-, ethyl ester
- CBNumber
- CB3855144
- Molecular Formula
- C8H14O3
- Formula Weight
- 158.2
- MOL File
- 5753-96-8.mol
Ethyl 2-oxohexanoate Property
- Boiling point:
- 96°C
- Density
- 0.981
- Flash point:
- 81°C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to green yellowLiquid
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B435023
- Product name
- Ethyl2-Oxohexanoate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- E12153
- Product name
- Ethyl2-oxohexanoate
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- W7093
- Product name
- Ethyl2-oxohexanoate
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- E12153
- Product name
- Ethyl2-oxohexanoate
- Purity
- 97.0%
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 075187
- Product name
- Ethyl 2-oxohexanoate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $162
- Updated
- 2021/12/16
Ethyl 2-oxohexanoate Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Synthesis Reference(s)
The Journal of Organic Chemistry, 29, p. 2080, 1964 DOI: 10.1021/jo01030a549
Synthesis
92273-73-9
4755-77-5
5753-96-8
General procedure for the synthesis of ethyl 2-oxohexanoate from n-butylzinc bromide and monoethyl oxalyl chloride: a stirred solution of copper iodide (2.29 g, 12 mmol) in anhydrous tetrahydrofuran was cooled to -25 °C and a tetrahydrofuran solution of 0.5 M n-butylzinc bromide (24 mL, 12 mmol) was added slowly dropwise. After addition, the reaction mixture was warmed to 0 °C and stirred at that temperature for 20 min, then cooled to -25 °C again. The reaction mixture was treated dropwise with monoethyl oxalyl chloride (1.37 g, 10 mmol). After stirring at -25 °C for 3 h, the reaction mixture was warmed to room temperature, the reaction was quenched with saturated aqueous ammonium chloride solution and the aqueous layer was extracted with ether. The combined organic phases were washed with brine, filtered, dried over anhydrous sodium sulfate and concentrated in vacuum. The crude product was purified by ISCO fast column chromatography using a pre-populated RediSep silica gel column (gradient elution, 0→20% ethyl acetate in hexane solution) to afford ethyl 2-oxohexanoate (0.60 g, 37%) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 0.91-0.98 (3H, m), 1.34- 1.47 (5H, m), 1.58-1.76 (2H, m), 2.83 (1H, t, J = 7.3 Hz), 4.27-4.37 (2H, m).
References
[1] Patent: US2008/90814, 2008, A1. Location in patent: Page/Page column 23-24
Ethyl 2-oxohexanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-oxohexanoate manufacturers
- Product
- Ethyl 2-oxohexanoate 5753-96-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- >100kg
- Release date
- 2021-07-13
- Product
- Ethyl 2-oxohexanoate 5753-96-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- Ethyl 2-oxohexanoate 5753-96-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09