8-Fluoro-4-chromanone
- Product Name
- 8-Fluoro-4-chromanone
- CAS No.
- 111141-00-5
- Chemical Name
- 8-Fluoro-4-chromanone
- Synonyms
- 8-Fluoro-4-chromanone;8-fluorochroman-4-one;8-FLUORO-4-OXO-CHROMAN;8-fluoro-2,3-dihydrochroMen-4-one;8-Fluoro-2,3-dihydro-4H-chromen-4-o;8-Fluoro-2,3-dihydro-4H-chromen-4-one;8-fluoro-3,4-dihydro-2H-1-benzopyran-4-one;5-fluoro-3,4-dihydro-2H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-fluoro-2,3-dihydro-;1H-Indene-2-carboxylicacid,4-bromo-2,7-dihydro-
- CBNumber
- CB3855210
- Molecular Formula
- C9H7FO2
- Formula Weight
- 166.15
- MOL File
- 111141-00-5.mol
8-Fluoro-4-chromanone Property
- Melting point:
- 84-87 °C
- Boiling point:
- 280.0±40.0 °C(Predicted)
- Density
- 1.297±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H7FO2/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3H,4-5H2
- InChIKey
- FKDMFDMYQZIZMI-UHFFFAOYSA-N
- SMILES
- C1OC2=C(F)C=CC=C2C(=O)C1
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F588433
- Product name
- 8-Fluorochroman-4-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2040AA
- Product name
- 8-Fluorochroman-4-one
- Packaging
- 250mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- AK-41267
- Product name
- 8-Fluorochroman-4-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 086011
- Product name
- 8-Fluoro-2,3-dihydro-4H-chromen-4-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $414
- Updated
- 2021/12/16
- Product number
- HCH0054456
- Product name
- 8-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.89
- Updated
- 2021/12/16
8-Fluoro-4-chromanone Chemical Properties,Usage,Production
Synthesis
2967-72-8
111141-00-5
General procedure for the synthesis of 8-fluorobenzodihydropyran-4-one from 3-(2-fluorophenoxy)propionic acid: oxalyl chloride (8.79 mL) and 1 drop of N,N-dimethylformamide (DMF) were added to a solution of 3-(2-fluorophenoxy)propionic acid (9.27 g) in dichloromethane (DCM, 50 mL) under ice-bath conditions. The reaction mixture was stirred at 0 °C for 2 h. Aluminum chloride (7.39 g, 55.42 mmol) was subsequently added. The reaction mixture was continued to be stirred at room temperature for 16 hours. After completion of the reaction, the mixture was poured into ice water and extracted three times with dichloromethane (DCM). The organic phases were combined and washed sequentially with 0.5 M sodium hydroxide (NaOH) solution and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography with the eluent of 20% ethyl acetate (EtOAc)/hexane (Hex) to afford the target product 8-fluorobenzodihydropyran-4-one (8.20 g, 98% yield).
References
[1] Patent: WO2006/108103, 2006, A1. Location in patent: Page/Page column 95; 96
[2] Patent: US2008/119496, 2008, A1. Location in patent: Page/Page column 12; 30
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 1, p. 230 - 243
[4] Patent: EP2913330, 2015, A1. Location in patent: Paragraph 0653
[5] Patent: WO2006/66950, 2006, A2. Location in patent: Page/Page column 33-36
8-Fluoro-4-chromanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Fluoro-4-chromanone manufacturers
- Product
- 8-Fluoro-4-chromanone 111141-00-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25