ChemicalBook > CAS DataBase List > Tilorone

Tilorone

Product Name
Tilorone
CAS No.
27591-97-5
Chemical Name
Tilorone
Synonyms
Tilorone;2,TILORONE;Tilorone USP/EP/BP;Bis-DEAE-fluorenone;Ethylamine fluorenone;2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone;2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one;9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-
CBNumber
CB3875201
Molecular Formula
C25H34N2O3
Formula Weight
410.55
MOL File
27591-97-5.mol
More
Less

Tilorone Property

Boiling point:
552.3±50.0 °C(Predicted)
Density 
1.102±0.06 g/cm3(Predicted)
pka
9.67±0.25(Predicted)
form 
Solid
color 
Orange to red
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
T440803
Product name
Tilorone
Packaging
2mg
Price
$60
Updated
2021/12/16
TRC
Product number
T440803
Product name
Tilorone
Packaging
10mg
Price
$90
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0143405
Product name
2,7-BIS[2-(DIETHYLAMINO)ETHOXY]-9-FLUORENONE
Purity
95.00%
Packaging
5MG
Price
$502.15
Updated
2021/12/16
AK Scientific
Product number
M961
Product name
Tilorone
Packaging
100mg
Price
$833
Updated
2021/12/16
More
Less

Tilorone Chemical Properties,Usage,Production

Uses

Tilorone is an orally active antiviral agent and interferon inducer that also has potential antineoplastic, immunomodulatory, and metabolic modulating effects. Tilorone induces an abnormally delayed interferon response and primarily stimulates interferon production in lymphoid tissue. Thus, Tilorone exerts antiviral effects and can be used as a chemotherapeutic agent. Tilorone has the potential to inhibit type 2 diabetes by increasing glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels[1][2][3][4][5].

Definition

ChEBI: Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. It has a role as an antiviral agent, an interferon inducer, an antineoplastic agent, an anti-inflammatory agent and a nicotinic acetylcholine receptor agonist. It is a member of fluoren-9-ones, a tertiary amino compound, an aromatic ether and a diether. It is a conjugate base of a tilorone(2+).

in vivo

Tilorone (50-250 mg/kg; po; single dose) can induce a delayed but not prolonged interferon response; and affects circulating interferon levels in a dose-dependent manner[1].
The maximum tolerated single dose of Tilorone in mice is 100 mg/kg; pharmacokinetic results of Tilorone (2, 10 mg/kg; ip) in mice indicate that Tilorone has a high absorption rate and is The half-life in mice is 18 hours, but exposure in male mice is higher[2].
Tilorone (25-50 mg/kg; ip; once daily for 8 days ) protects 90% of Ebola virus-infected mice from lethal challenge[2].
Tilorone (25 mg/kg; iv; single dose) enhances immunity in small Uptake of the radiolabeled glucose analog 18F-fluoro-2-deoxyglucose in rats[3].

Animal Model:6-week-old female mouse[1]
Dosage:250 mg/kg
Administration:po; single dose
Result:Resulted in correspondingly lower levels of circulating interferon, although moderately high levels were obtained (2,500 units/ml) with as little as 50 mg/kg. Interferon production was not detected in the upper gastrointestinal tract.
Animal Model:Ebola virus disease (EVD) infected mouse model[2]
Dosage:25 mg/kg, 30 mg/kg, 50 mg/kg
Administration:ip; once daily for 8 days
Result:Showed was fully protective effect at 30 mg/kg, starting 2 or 24 h postchallenge and continuing through day 7 postinfection.
Animal Model:C57BL/6 mouse[3]
Dosage:25 mg/kg
Administration:IV; in 100?μL saline via the lateral tail vein
Result:Significant increased in the SUV mean of skeletal muscle, adipose tissue, and liver.

References

[1] Stringfellow D A, et al. Tilorone hydrochloride: an oral interferon-inducing agent[J]. Antimicrobial agents and chemotherapy, 1972, 2(2): 73-78. DOI:10.1128/AAC.2.2.73
[2] Ekins S, et al. Efficacy of tilorone dihydrochloride against Ebola virus infection[J]. Antimicrobial agents and chemotherapy, 2018, 62(2): 10.1128/aac. 01711-17. DOI:10.1128/AAC.01711-17
[3] Kohler Z M, et al. Tilorone increases glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels[J]. Journal of Cellular Physiology, 2023, 238(5): 1080-1094. DOI:10.1002/jcp.30998
[4] Wissing M D, et al. Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression[J]. Oncology reports, 2014, 32(1): 419-424.

Tilorone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Tilorone Suppliers

China 45 India 2 United States 2 Global 49
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Zhejiang Haiqiang Chemical Co.,Ltd
Tel
0571-86050367 0571-86960370 0571-86050387
Fax
0571-86940780
Email
info@chinahaiqiangchem.com
Country
China
ProdList
462
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Baoji Guokang Healthchem co.,ltd
Tel
+8615604608665 15604608665
Email
dominicguo@gk-bio.com
Country
CHINA
ProdList
9414
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15109
Advantage
58
SIMAGCHEM CORP
Tel
+86-5922680277 +86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17346
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 13298656710
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
7448
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Wuhan lanabai Pharmaceutical Chemical Co., Ltd
Tel
15307151931
Fax
QQ-2355680
Email
2355680@qq.com
Country
China
ProdList
5831
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-029-81024372 17792795018
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10003
Advantage
58
Mainchem Co., Ltd.
Tel
--
Fax
--
Email
sarah@mainchem.com
Country
China
ProdList
6547
Advantage
58
Hubei Xinkang Pharmaceutical Chemical Co., Ltd
Tel
027-027-59308705 18871579363
Fax
027-59308705
Email
1248680011@qq.com
Country
China
ProdList
9850
Advantage
58
Hubei Baidu Chemical Co., Ltd
Tel
027-027-59106051 13627137652
Fax
027-59223020
Email
1438180055@qq.com
Country
China
ProdList
8750
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
+86-0755-66853366 +86-13670046396
Email
export03@qcsrm.com
Country
China
ProdList
24342
Advantage
58
Shanghai Gukang Biotechnology Co., LTD
Tel
13564510648
Fax
021-54301252
Email
2985380065@qq.com
Country
China
ProdList
111
Advantage
58
Wuhan Lvjing Fenghua Biotechnology Co., Ltd.
Tel
19972070065
Email
201746457@qq.com
Country
China
ProdList
6428
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Hubei DAHAO Chemical Co., Ltd.
Tel
027-027-59106191 13986034860
Email
1400828855@qq.com
Country
China
ProdList
8919
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Huayin Sample Biological Technology Co. LTD
Tel
13892502238
Email
1453186328@qq.com
Country
China
ProdList
803
Advantage
58
Hubei Chenghai Chemical Co., Ltd
Tel
027-59220433 18327245847
Email
1400838877@qq.com
Country
China
ProdList
9875
Advantage
58
guoyungurui
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
10335
Advantage
58
Yantai Shengkailun Chemical Technology Co., Ltd.
Tel
13356901049
Email
mark@sklnchem.cn
Country
China
ProdList
9995
Advantage
58
Wuhan Noble Pharmaceutical&Chemical Co.Ltd.
Tel
027-027-87827088 18986164924
Email
3925824740@QQ.COM
Country
China
ProdList
2670
Advantage
58
Shaanxi Istare Biotechnology Co., Ltd.
Tel
18682931470; 18682931470
Email
2142355700@qq.com
Country
China
ProdList
4723
Advantage
58
Shanghai jerryxing Biomedical Technology Co., Ltd
Tel
17721492509; 17721492509
Email
643638326@qq.com
Country
China
ProdList
4968
Advantage
58
Changsha Fuzhen Biotechnology Co.，LTD
Tel
0731-13823398 15111215862
Email
313359644@qq.com
Country
China
ProdList
4161
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-59102966 18717199209
Email
2853877583@QQ.com
Country
China
ProdList
7498
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Email
sales@coreychem.com
Country
China
ProdList
29847
Advantage
58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
Tel
+8618950047208
Email
ellena@amitychem.com
Country
China
ProdList
43416
Advantage
58
Shenzhen Zuoke Biotechnology Co., Ltd.
Tel
13532174601
Country
CHINA
ProdList
109
Advantage
58
Beijing Pubiao Technology Co., Ltd.
Tel
18618179058
Country
CHINA
ProdList
122
Advantage
58
Guangzhou Dedou Life Science Co., Ltd
Tel
Country
CHINA
ProdList
0
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Xian Terra Biochem Co., Ltd
Tel
--
Fax
--
Email
Info@terrabiochem.com
Country
China
ProdList
155
Advantage
38
Hangzhou Rongkang Chemical Co., Ltd
Tel
--
Fax
--
Email
rongkang@rongkangchem.com
Country
China
ProdList
119
Advantage
66
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
Advantage
56
Shanghai New Union Textra Import & Export Co., Ltd
Tel
--
Fax
--
Email
zhou@pharmchemical.com
Country
China
ProdList
2748
Advantage
60
More
Less

View Lastest Price from Tilorone manufacturers

Dideu Industries Group Limited
Product
Tilorone 27591-97-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-15
Career Henan Chemical Co
Product
Tilorone 27591-97-5
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200kg
Release date
2019-08-30

27591-97-5, TiloroneRelated Search:

DIETHOXYMETHANE 2-Ethoxyethanol Amitriptyline hydrochloride Ethoxyquin 2-Ethoxyphenol Diethoxymethyl acetate Phenylfluorone Lithium bis(trimethylsilyl)amide TILORONE 2HCL,TILORONE DIHYDROCHLORIDE,TILORONE HYDROCHLORIDE 9-Fluorenone Ethoxy Tilorone Tilorone dihydrochioride dihydrate Tilorone Analog R 10,556 DA TILORONE ANALOG R11-877DA Tilorone Analog R 11,043 DA TILORONE ANALOG R11-567DA

  • Tilorone
  • 2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone
  • 2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
  • Bis-DEAE-fluorenone
  • 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
  • 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-
  • Tilorone USP/EP/BP
  • 2,TILORONE
  • Ethylamine fluorenone
  • 27591-97-5
  • C25H34N2O3