trofosfamide

Product Name: trofosfamide
CAS No.: 22089-22-1
Chemical Name: trofosfamide
Synonyms: A-4828;Ccris 4442;Brn 0532530;Asta Z 4828;trofosfamide;TROPHOSPHAMIDE;Trofosfamide,Bacterial,Inhibitor,inhibit;2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9ci);3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide;3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide
CBNumber: CB3877124
Molecular Formula: C9H18Cl3N2O2P
Formula Weight: 323.58
MOL File: 22089-22-1.mol

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trofosfamide Property

Melting point:: 47-49°C
alpha: D25 -28.6° (c = 2 in CH3OH)
Boiling point:: 104°C
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF: 50mg/mL; DMSO: 30mg/mL; Ethanol: 50mg/mL; PBS (pH 7.2): 10mg/mL
form: A crystalline solid
pka: -0.46±0.20(Predicted)

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Safety

Toxicity: LD50 i.p. in mice: 212 mg/kg (Brock, Potel)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21874
Product name: Trofosfamide
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21874
Product name: Trofosfamide
Packaging: 10mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 21874
Product name: Trofosfamide
Packaging: 25mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21874
Product name: Trofosfamide
Packaging: 50mg
Price: $169
Updated: 2024/03/01

ChemScene

Product number: CS-0078076
Product name: Trofosfamide
Purity: >98.0%
Packaging: 50mg
Price: $200
Updated: 2021/12/16

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trofosfamide Chemical Properties,Usage,Production

Chemical Properties

Off-White Low Melting Solid

Originator

Ixoten,Asta,W. Germany,1973

Uses

Antineoplastic; one derivative

Definition

ChEBI: Trofosfamide is a member of ifosfamides.

Manufacturing Process

259 g (1 mol) of N,N-bis-(2-chloroethyl)-phosphoric acid amide dichloride, 209 g (1.2 mols) of N-(2-chloroethyl)-N-(3-hydroxypropyl)-amine hydrochloride (crude), 1,000 cc of ethylene dichloride and 344 g (3.4 mols) of triethylamine are the reactants. N,N-bis-(2-chloroethyl)-phosphoric acid amide dichloride is dissolved in the methylene dichloride. N-(2-chloroethyl)-N-(3- hydroxypropyl)-amine hydrochloride is suspended in this solution and triethylamine is added thereto dropwise with stirring. The temperature of the solution rises to boiling, After the termination of the addition, the mixture is heated to boiling for another 6 hours. Thereafter, the reaction mixture is cooled down and allowed to stand overnight at about 0°C. The precipitated triethylamine hydrochloride is filtered off with suction. The resulting solution is evaporated, the residue (about 370 g) is triturated with about 3.2 liters of ether and is heated to boiling for a short period of time.
The ethereal solution is decanted from the insolubles (about 90 g). The solution is rendered to pH 6.5 to 7 by the addition of ethereal hydrochloric acid and then is filtered over charcoal and thereafter is evaporated. During evaporation, the temperature should not rise above 40°C. The residue is dissolved in ether and in an amount corresponding to half of its weight (240 g of residue, dissolved in 120 cc of ether), the ethereal solution is cooled to - 5°C and is inoculated. After standing for 25 hours, 140 g have been separated by crystallization. After separation by filtration with suction, the mother liquor is diluted with ether to 5 times its volume, the solution is filtered over charcoal, is again evaporated and the residue is again dissolved in a volume corresponding to half of the weight of the residue. Another cooling to -5°C and inoculation produces further 18 g of the desired compound. MP: 50° to 51°C. Total yield: 161 g (50% of the theoretical)

Therapeutic Function

Cancer chemotherapy

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and POx.

trofosfamide Preparation Products And Raw materials

Raw materials

Preparation Products

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trofosfamide Suppliers

Canada 1 China 27 Europe 1 India 1 South Korea 1 United States 6 Global 37

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22089-22-1, trofosfamide Related Search:

OXYPHENYL BUTAZONE Ammonium dihydrogen phosphate Cyclic adenosine monophosphate PHOSPHAMIDON Cyclophosphamide dechloroethylcyclophosphamide Ifosfamide trofosfamide dechloroethylifosfamide phosphoramide mustard

trofosfamide

TROPHOSPHAMIDE

2-(Bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9ci)

2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-, 2-oxide

3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide

3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide

A-4828

Asta Z 4828

Brn 0532530

Ccris 4442

Trofosfamide,Bacterial,Inhibitor,inhibit

22089-22-1

C9H18Cl3N2O2P

C9H14D4Cl3N2O2P

Heterocycles

Intermediates & Fine Chemicals

Isotope Labelled Compounds

Pharmaceuticals