Thioproperazine
- Product Name
- Thioproperazine
- CAS No.
- 316-81-4
- Chemical Name
- Thioproperazine
- Synonyms
- Vontil;Megeptil;Mazeptyl;Majeptyl;Cephalmin;Sulfenazin;hioproperazine;thioproperazine;N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester;N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
- CBNumber
- CB3912908
- Molecular Formula
- C22H30N4O2S2
- Formula Weight
- 446.63
- MOL File
- 316-81-4.mol
Thioproperazine Property
- Melting point:
- 140°
- Boiling point:
- 612.2±65.0 °C(Predicted)
- Density
- 1.1476 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.65±0.10(Predicted)
- NIST Chemistry Reference
- Thioproperazine(316-81-4)
Safety
- Toxicity
- LD50 oral in mouse: 830mg/kg
N-Bromosuccinimide Price
- Product number
- PH003261
- Product name
- N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $172
- Updated
- 2023/06/20
- Product number
- CD11146489
- Product name
- Thioproperazine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CD11146489
- Product name
- Thioproperazine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $665
- Updated
- 2021/12/16
- Product number
- CD11146489
- Product name
- Thioproperazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $1664
- Updated
- 2021/12/16
Thioproperazine Chemical Properties,Usage,Production
Originator
Majeptil,Specia,France,1960
Definition
ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.
Manufacturing Process
A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1- piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is added and the mixture heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)- phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C.
Therapeutic Function
Neuroleptic, Antiemetic
Thioproperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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