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Thioproperazine

Product Name
Thioproperazine
CAS No.
316-81-4
Chemical Name
Thioproperazine
Synonyms
Vontil;Megeptil;Mazeptyl;Majeptyl;Cephalmin;Sulfenazin;hioproperazine;thioproperazine;N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester;N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
CBNumber
CB3912908
Molecular Formula
C22H30N4O2S2
Formula Weight
446.63
MOL File
316-81-4.mol
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Thioproperazine Property

Melting point:
140°
Boiling point:
612.2±65.0 °C(Predicted)
Density 
1.1476 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Solid
pka
7.65±0.10(Predicted)
color 
Light yellow to yellow
NIST Chemistry Reference
Thioproperazine(316-81-4)
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Safety

Toxicity
LD50 oral in mouse: 830mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PH003261
Product name
N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide
Purity
AldrichCPR
Packaging
1MG
Price
$172
Updated
2023/06/20
Crysdot
Product number
CD11146489
Product name
Thioproperazine
Purity
97%
Packaging
100mg
Price
$416
Updated
2021/12/16
Crysdot
Product number
CD11146489
Product name
Thioproperazine
Purity
97%
Packaging
250mg
Price
$665
Updated
2021/12/16
Crysdot
Product number
CD11146489
Product name
Thioproperazine
Purity
97%
Packaging
1g
Price
$1664
Updated
2021/12/16
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Thioproperazine Chemical Properties,Usage,Production

Originator

Majeptil,Specia,France,1960

Definition

ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1- piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is added and the mixture heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)- phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C.

Therapeutic Function

Neuroleptic, Antiemetic

Thioproperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Thioproperazine Suppliers

Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
ShangHai Movin Pharmaceutical Co., Ltd.
Tel
13681854265
Email
info@moenpharm.com
Country
China
ProdList
509
Advantage
55
Shanghai Zhixin Chemical Technology Co., Ltd.
Tel
021-60441077 18701958033
Fax
021-60441077
Email
shzxchem@163.com
Country
China
ProdList
598
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15494
Advantage
58
Zhengzhou Ruke Biological Co., Ltd.
Tel
15981811963
Fax
QQ:1410472904
Email
1410472904@qq.com
Country
China
ProdList
5825
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30238
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
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View Lastest Price from Thioproperazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Thioproperazine 316-81-4
Price
US $1.00/G
Min. Order
1G
Purity
98%
Supply Ability
100G
Release date
2024-05-22

316-81-4, ThioproperazineRelated Search:


  • thioproperazine
  • N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
  • 10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • Cephalmin
  • Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • Sulfenazin
  • N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester
  • hioproperazine
  • Majeptyl
  • Mazeptyl
  • Megeptil
  • Vontil
  • 316-81-4
  • C22H30N4O2S2