ChemicalBook > CAS DataBase List > colchiceine

colchiceine

Product Name
colchiceine
CAS No.
477-27-0
Chemical Name
colchiceine
Synonyms
NSC 3341;NSC 33411;colchiceine;O10-Demethylcolchicine;Colchicine EP Impurity F;N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim;Colchicine Impurity 6(Colchicine EP Impurity F);N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide;(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one;(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
CBNumber
CB3916380
Molecular Formula
C21H23NO6
Formula Weight
385.41
MOL File
477-27-0.mol
More
Less

colchiceine Property

Melting point:
172-1740C
alpha 
D25 -255.1° (c = 1 in chloroform)
Boiling point:
511.86°C (rough estimate)
Density 
1.2400
refractive index 
1.5614 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.59±0.40(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
More
Less

Safety

Toxicity
LD50 intraperitoneal in mouse: 84mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H318Causes serious eye damage

H330Fatal if inhaled

H340May cause genetic defects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
C638500
Product name
Colchiceine
Packaging
50mg
Price
$320
Updated
2021/12/16
Usbiological
Product number
007021
Product name
Colchiceine
Packaging
10mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000488
Product name
COLCHICEINE
Purity
95.00%
Packaging
10MG
Price
$721.88
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20539
Product name
Colchiceine
Packaging
250mg
Price
$1000
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20539
Product name
Colchiceine
Packaging
500mg
Price
$1500
Updated
2021/12/16
More
Less

colchiceine Chemical Properties,Usage,Production

Description

Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.

Chemical Properties

Off- White to Pale Yellow Solid

Uses

A metabolite of Colchicine

Definition

ChEBI: Colchiceine is a cyclic ketone.

Trade name

Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).

colchiceine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

colchiceine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18043
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
Shanghai Yihe Biological Technology Co., Ltd.
Tel
17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
3683
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8888
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
More
Less

View Lastest Price from colchiceine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
colchiceine 477-27-0
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
420000KG
Release date
2024-08-05
Wuhan ChemNorm Biotech Co.,Ltd.
Product
Colchiceine 477-27-0
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
98%
Supply Ability
1000MG
Release date
2020-08-05

477-27-0, colchiceineRelated Search:


  • Colchicine EP Impurity F
  • (S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • colchiceine
  • N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
  • NSC 3341
  • O10-Demethylcolchicine
  • NSC 33411
  • Colchicine Impurity 6(Colchicine EP Impurity F)
  • N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim
  • Acetamide, N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
  • (S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
  • N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide
  • 477-27-0
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals