ChemicalBook > CAS DataBase List > colchiceine

colchiceine

Product Name
colchiceine
CAS No.
477-27-0
Chemical Name
colchiceine
Synonyms
NSC 3341;NSC 33411;colchiceine;O10-Demethylcolchicine;Colchicine EP Impurity F;N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim;Colchicine Impurity 6（Colchicine EP Impurity F）;N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide;(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one;(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
CBNumber
CB3916380
Molecular Formula
C21H23NO6
Formula Weight
385.41
MOL File
477-27-0.mol
More
Less

colchiceine Property

Melting point:
172-1740C
alpha 
D25 -255.1° (c = 1 in chloroform)
Boiling point:
511.86°C (rough estimate)
Density 
1.2400
refractive index 
1.5614 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.59±0.40(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
More
Less

Safety

Toxicity
LD50 intraperitoneal in mouse: 84mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H318Causes serious eye damage

H330Fatal if inhaled

H340May cause genetic defects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
C638500
Product name
Colchiceine
Packaging
50mg
Price
$320
Updated
2021/12/16
Usbiological
Product number
007021
Product name
Colchiceine
Packaging
10mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000488
Product name
COLCHICEINE
Purity
95.00%
Packaging
10MG
Price
$721.88
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20539
Product name
Colchiceine
Packaging
250mg
Price
$1000
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20539
Product name
Colchiceine
Packaging
500mg
Price
$1500
Updated
2021/12/16
More
Less

colchiceine Chemical Properties,Usage,Production

Description

Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.

Chemical Properties

Off- White to Pale Yellow Solid

Uses

A metabolite of Colchicine

Definition

ChEBI: Colchiceine is a cyclic ketone.

Trade name

Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).

colchiceine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

colchiceine Suppliers

Canada 1 China 54 Germany 1 India 7 United Kingdom 1 United States 5 Global 69
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
Shanghai Yihe Biological Technology Co., Ltd.
Tel
17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
3990
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8899
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9881
Advantage
58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
Email
2399235533@qq.com
Country
China
ProdList
4933
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
8897
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2123
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
Country
China
ProdList
7774
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30240
Advantage
58
Wuhan ChemNorm Biotech Co.,Ltd.
Tel
+86-27-8439 4403 18971486879
Fax
+86-27-8439 4403
Email
sales@chemnorm.com
Country
CHINA
ProdList
2935
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
18192627656
Fax
+86-29-88380327
Email
1012@dideu.com
Country
China
ProdList
3002
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
info@synzest.com
Country
China
ProdList
9286
Advantage
58
Shanghai Hewu Biotechnology Co., LTD
Tel
021-57886085 17317861055
Email
shhebio@126.com
Country
CHINA
ProdList
7974
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
10784
Advantage
58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10002
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
Shanghai Taopu Industrial Co., LTD
Tel
18018507602 15900573766
Email
394643792@qq.com
Country
China
ProdList
3025
Advantage
58
Molcoo Chemicals Inc.
Tel
18627756402
Email
3001051413@qq.com
Country
China
ProdList
9544
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
18080489829
Email
3004654993@qq.com
Country
China
ProdList
9209
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
10005
Advantage
58
Shanghai Moqi Biological Technology Co., LTD
Tel
021-38218169 13341702378
Email
190129269@qq.com
Country
China
ProdList
9126
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175-877 18933936954
Email
tianwen.zhan@cato-chem.com
Country
China
ProdList
7735
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
15583
Advantage
58
Naturewill Biotechnology Co., Ltd.
Tel
18113192475 18113192475
Email
3157321941@qq.com
Country
China
ProdList
5001
Advantage
58
Nanjing Huanuo Biomedical Technology Co., Ltd
Tel
18913906212
Email
2885426135@qq.com
Country
China
ProdList
7010
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-400-8210725
Email
malulu@leyan.com
Country
China
ProdList
39953
Advantage
58
Shureli Biopharma Co.,Ltd
Tel
0871-68355600 18787766125
Email
756338076@qq.com
Country
China
ProdList
612
Advantage
58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd
Tel
18502726233; 18502726233
Email
3641133981@qq.com
Country
China
ProdList
9705
Advantage
58
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd
Tel
18102736234 18102736234
Email
2208093734@qq.com
Country
China
ProdList
7664
Advantage
58
Hubei CuiRan Biotechnology Co., Ltd.
Tel
18162791556
Email
3152548389@qq.com
Country
China
ProdList
4351
Advantage
58
RENI Pharmaceutical Technology Co., Ltd
Tel
028-87865381 18108190480
Email
2881944542@qq.com
Country
China
ProdList
3302
Advantage
58
Cato Research Chemicals Inc.
Tel
13342851930
Email
3008394369@qq.com
Country
China
ProdList
15726
Advantage
58
Mensura Group Limited
Tel
18109034517
Fax
028-87362290
Email
18109034517@163.com
Country
China
ProdList
2898
Advantage
58
Shanghai Daken Advanced Materials Co.,Ltd
Tel
+86-371-66670886
Email
info@dakenam.com
Country
China
ProdList
18779
Advantage
58
Mensura Group Limited
Tel
+8618109034517
Fax
028-87362290
Email
hkd008@vacorda.com
Country
China
ProdList
2900
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
+8618080483897
Email
sales@biopurify.com
Country
China
ProdList
3772
Advantage
58
China National Standard Pharmaceutical Corporation Limited
Tel
+8615391658522
Email
overseasales@yongstandards.com
Country
China
ProdList
11922
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6184
Advantage
58
More
Less

View Lastest Price from colchiceine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
colchiceine 477-27-0
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
420000KG
Release date
2024-08-05
Wuhan ChemNorm Biotech Co.,Ltd.
Product
Colchiceine 477-27-0
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
98%
Supply Ability
1000MG
Release date
2020-08-05

477-27-0, colchiceineRelated Search:

Cinnamtannin D1 ProtopluMericin A Colchicine [epicatechin-(4beta->8)]5-epicatechin colchiceine COLCHICOSIDE COLCHICINE, [RING C, METHOXY-14C] COLCHICINE-D6 COLCHICINE-D3 Colchicine, N-methyl- COLCHICINE METHANETHIOSULFONATE COLCHICEINE-D3 N-TRIFLUOROACETYL DEACETYLCOLCHICINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICINE N-TRIFLUOROACETYL DEACETYLCOLCHICEINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICEINE COLCHICINE, [RING C, METHOXY-3H] COLCHICINE SALICYLATED

  • Colchicine EP Impurity F
  • (S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • colchiceine
  • N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
  • NSC 3341
  • O10-Demethylcolchicine
  • NSC 33411
  • Colchicine Impurity 6（Colchicine EP Impurity F）
  • N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim
  • Acetamide, N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
  • (S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
  • N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide
  • 477-27-0
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals