colchiceine

ChemicalBook > CAS DataBase List > colchiceine

Product Name: colchiceine
CAS No.: 477-27-0
Chemical Name: colchiceine
Synonyms: NSC 3341;NSC 33411;colchiceine;O10-Demethylcolchicine;Colchicine EP Impurity F;N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim;Colchicine Impurity 6（Colchicine EP Impurity F）;N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide;(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one;(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
CBNumber: CB3916380
Molecular Formula: C21H23NO6
Formula Weight: 385.41
MOL File: 477-27-0.mol

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colchiceine Property

Melting point:: 172-1740C
alpha: D25 -255.1° (c = 1 in chloroform)
Boiling point:: 511.86°C (rough estimate)
Density: 1.2400
refractive index: 1.5614 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 7.59±0.40(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Safety

Toxicity: LD50 intraperitoneal in mouse: 84mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H318Causes serious eye damage

H330Fatal if inhaled

H340May cause genetic defects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C638500
Product name: Colchiceine
Packaging: 50mg
Price: $320
Updated: 2021/12/16

Usbiological

Product number: 007021
Product name: Colchiceine
Packaging: 10mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000488
Product name: COLCHICEINE
Purity: 95.00%
Packaging: 10MG
Price: $721.88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20539
Product name: Colchiceine
Packaging: 250mg
Price: $1000
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20539
Product name: Colchiceine
Packaging: 500mg
Price: $1500
Updated: 2021/12/16

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colchiceine Chemical Properties,Usage,Production

Description

Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.

Chemical Properties

Off- White to Pale Yellow Solid

Uses

A metabolite of Colchicine

Definition

ChEBI: Colchiceine is a cyclic ketone.

Trade name

Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).

colchiceine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from colchiceine manufacturers

Wuhan ChemNorm Biotech Co.,Ltd.

Product: Colchiceine 477-27-0
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%
Supply Ability: 1000MG
Release date: 2020-08-05

477-27-0, colchiceineRelated Search:

Cinnamtannin D1 ProtopluMericin A Colchicine [epicatechin-(4beta->8)]5-epicatechin colchiceine COLCHICOSIDE COLCHICINE, [RING C, METHOXY-14C] COLCHICINE-D6 COLCHICINE-D3 Colchicine, N-methyl- COLCHICINE METHANETHIOSULFONATE COLCHICEINE-D3 N-TRIFLUOROACETYL DEACETYLCOLCHICINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICINE N-TRIFLUOROACETYL DEACETYLCOLCHICEINE N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICEINE COLCHICINE, [RING C, METHOXY-3H] COLCHICINE SALICYLATED

Colchicine EP Impurity F

(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one

colchiceine

N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide

NSC 3341

O10-Demethylcolchicine

NSC 33411

Colchicine Impurity 6（Colchicine EP Impurity F）

N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim

Acetamide, N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide

477-27-0

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals