colchiceine Property

Melting point:

172-1740C

alpha 

D25 -255.1° (c = 1 in chloroform)

Boiling point:

511.86°C (rough estimate)

Density 

1.2400

refractive index 

1.5614 (estimate)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

7.59±0.40(Predicted)

form 

Solid

color 

Off-White to Pale Yellow

Safety

Toxicity

LD50 intraperitoneal in mouse: 84mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H318Causes serious eye damage

H330Fatal if inhaled

H340May cause genetic defects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

colchiceine Chemical Properties,Usage,Production

Description

Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.

Chemical Properties

Off- White to Pale Yellow Solid

Uses

A metabolite of Colchicine

Definition

ChEBI: Colchiceine is a cyclic ketone.

Trade name

Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).