Geldanamycin-FITC
- Product Name
- Geldanamycin-FITC
- CAS No.
- 2969156-01-0
- Chemical Name
- Geldanamycin-FITC
- Synonyms
- Geldan-FITC;Geldanamycin-FITC
- CBNumber
- CB39272847
- Formula Weight
- 0
- MOL File
- Mol file
Geldanamycin-FITC Property
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (greater than 10 mg/ml)
- form
- solid
- color
- Purple
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML1277
- Product name
- Geldanamycin-FITC
- Purity
- ≥98% (HPLC), from <I>Streptomyces hygroscopicus</I>
- Packaging
- 1 mg
- Price
- $328
- Updated
- 2025/07/31
Geldanamycin-FITC Chemical Properties,Usage,Production
Description
Geldanamycin-FITC is a novel geldanamycin fluorescent probe1?that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3?May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of?in vitro?pharmacology to cellular and?in vivo?efficacy.4
Uses
Geldanamycin-FITC is a novel geldanamycin fluorescent probe. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.
IC 50
HSP90
References
[1] LAURA LLAUGER-BUFI . Synthesis of novel fluorescent probes for the molecular chaperone Hsp90[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 22: Pages 3975-3978. DOI:10.1016/j.bmcl.2003.08.065
[2] JOUNGNAM KIM . Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90[J]. SLAS Discovery, 2004, 9 5: Pages 375-381. DOI:10.1177/1087057104265995
[3] CAROL AUSTIN . Fragment Screening Using Capillary Electrophoresis (CEfrag) for Hit Identification of Heat Shock Protein 90 ATPase Inhibitors[J]. SLAS Discovery, 2012, 17 7: Pages 868-876. DOI:10.1177/1087057112445785
[4] LATA T GOOLJARSINGH. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 7625-7630. DOI:10.1073/pnas.0602650103
Geldanamycin-FITC Preparation Products And Raw materials
Raw materials
Preparation Products
Geldanamycin-FITC Suppliers
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