Sodium theophylline glycinate

Product Name: Sodium theophylline glycinate
CAS No.: 8000-10-0
Chemical Name: Sodium theophylline glycinate
Synonyms: Sodium theophylline glycite;Sodium theophylline glycinate;Sodium theophylline glycinate USP/EP/BP;THEOPHYLLINE SODIUM GLYCINATE USP/EP/BP;Sodium 2-aminoacetate 1,3-dimethyl-7H-purine-2,6-dione
CBNumber: CB3947290
Molecular Formula: C9H12N5NaO4
Formula Weight: 277.21
MOL File: 8000-10-0.mol

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Sodium theophylline glycinate Property

Density: d20 1.05

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: AAA0006404
Product name: THEOPHYLLINE SODIUM GLYCINATE
Purity: 95.00%
Packaging: 5MG
Price: $499.77
Updated: 2021/12/16

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Sodium theophylline glycinate Chemical Properties,Usage,Production

Uses

Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

in vivo

Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice^[1].

Animal Model:	Male Swiss mice^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; daily; for 9 days
Result:	Increased IL-6 and IL-10 levels and inhibited TNF-α and NO.

IC 50

IL-10; IL-6

References

[1] Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. PMID:7664866
[2] Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5. DOI:10.1097/00024382-199705000-00010
[3] Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. DOI:10.1073/pnas.132556899
[4] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. DOI:10.1164/rccm.201302-0388PP

Sodium theophylline glycinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium theophylline glycinate Suppliers

China 43 Germany 1 India 4 United Kingdom 1 United States 3 Global 52

XiaoGan ShenYuan ChemPharm co,ltd

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View Lastest Price from Sodium theophylline glycinate manufacturers

Career Henan Chemical Co

Product: Sodium theophylline glycinate 8000-10-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: 1ton
Release date: 2019-12-18

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