ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE &
Uses- Product Name
- ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE &
- CAS No.
- 145143-60-8
- Chemical Name
- ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE &
- Synonyms
- Ethyl 1-aMinocyclobutanecarboxylate;Ethyl 1-aminocyclobutanecarboxylate HCl;Ethyl 1-aminocyclobutanecarboxylate hydrochloride;1-AMino-cyclobutanecarboxylic acid ethyl ester HCl;ethyl 1-aminocyclobutane-1-carboxylate hydrochloride;Ethyl 1-aMino-1-cyclobutanecarboxylateMono hydrochloride,97%;1-Aminocyclobutane-1-carboxylic acid ethyl ester hydrochloride;Cyclobutanecarboxylic acid, 1-aMino-, ethyl ester, hydrochloride;Cyclobutanecarboxylic acid, 1-amino-, ethyl ester, hydrochloride (1:1)
- CBNumber
- CB3972315
- Molecular Formula
- C7H13NO2HCl
- Formula Weight
- 179.65
- MOL File
- 145143-60-8.mol
ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE & Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H13NO2.ClH/c1-2-10-6(9)7(8)4-3-5-7;/h2-5,8H2,1H3;1H
- InChIKey
- YGAYWFFKRVMVBL-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C1(CCC1)N.Cl
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36-42/43
- Safety Statements
- 26-36-36/37-22
- WGK Germany
- 3
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 596981
- Product name
- Ethyl 1-amino-1-cyclobutanecarboxylate monohydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $147
- Updated
- 2023/06/20
- Product number
- E900180
- Product name
- Ethyl1-aminocyclobutanecarboxylatehydrochloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-M2531
- Product name
- Cyclobutanecarboxylicacid,1-amino-,ethylester(hydrochloride)(1:1)
- Packaging
- 25g
- Price
- $776
- Updated
- 2021/12/16
- Product number
- CS-M2531
- Product name
- Cyclobutanecarboxylicacid,1-amino-,ethylester(hydrochloride)(1:1)
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- CHM0017687
- Product name
- 1-AMINO-CYCLOBUTANE-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1784.48
- Updated
- 2021/12/16
ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE & Chemical Properties,Usage,Production
Uses
1-Aminocyclobutanecarboxylate hydrochloride is a carboxylic acid ester compound that can be used as a pharmaceutical intermediate.
Synthesis
Sodium azide (3.14 g, 48.3 mmol) was partially dissolved in dry DMSO (50 mL) under nitrogen atmosphere at room temperature. ethyl 1-bromocyclobutanecarboxylate (3.91 mL, 24.2 mmol, Aldrich) was then added via syringe. The mixture was heated at 40 ??C for 7 h to obtain a homogeneous solution, cooled to room temperature with continuous stirring overnight. The reaction mixture was then poured into water (700 mL) and ether (200 mL) was added. The ether layer was washed three times with half the concentration of brine and once more with brine. The organic layer was dried with sodium sulfate, filtered and distilled under reduced pressure to give ethyl 1-azido cyclobutanecarboxylate (4.00 g) as a clarified oil.
Ethyl 1-azido cyclobutanecarboxylate (4.00 g, 23.6 mmol) was dissolved in methanol (150 mL) under nitrogen atmosphere. Palladium carbon (840 mg, 10% wt/wt) was then added and hydrogen was passed through to remove the nitrogen. the reaction was judged to be complete after 3 hr (LCMS). The reaction mixture was filtered through diatomaceous earth, which was washed with methanol. The combined methanol solutions were made acidic by the addition of HCl (2.0 M in ether) and the solvent was then removed under reduced pressure. The 1-aminocyclobutanecarboxylic acid ethyl ester hydrochloride (4.70 g) obtained then slowly solidified to a low melting point waxy solid containing a considerable amount of methanol as determined by proton NMR.
ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE & Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE & Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11999
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-58955608,2250286 15921236618
- blinkzeng@gmail.com
- Country
- China
- ProdList
- 522
- Advantage
- 62
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from ETHYL 1-AMINO-1-CYCLOBUTANECARBOXYLATE & manufacturers
- Product
- Ethyl 1-aminocyclobutanecarboxylate HCl 145143-60-8
- Price
- US $0.37/g
- Min. Order
- 1g
- Purity
- 99%min cherry@coreychem.com
- Supply Ability
- 1kg/10kg
- Release date
- 2020-11-29