KARAKOLINE

ChemicalBook > CAS DataBase List > KARAKOLINE

Product Name: KARAKOLINE
CAS No.: 39089-30-0
Chemical Name: KARAKOLINE
Synonyms: Karacoline;Carmicheline(7CI);Karacoline, 10 mM in DMSO;Inhibitor,Karacoline,inhibit;(16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol;(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol;Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-;Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-;11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.
CBNumber: CB3986952
Molecular Formula: C22H35NO4
Formula Weight: 377.52
MOL File: 39089-30-0.mol

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KARAKOLINE Property

Melting point:: 185-186℃ (acetone )
Boiling point:: 540.2±50.0 °C(Predicted)
Density: 1.30±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
form: Solid
pka: 13.80±0.70(Predicted)
color: White to off-white

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Safety

RTECS: AR5569480

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: K139700
Product name: Karacoline
Packaging: 1mg
Price: $140
Updated: 2021/12/16

TRC

Product number: K139700
Product name: Karacoline
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ApexBio Technology

Product number: N2030
Product name: Karacoline
Packaging: 20mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-0027924
Product name: Karacoline
Packaging: 10mg
Price: $743
Updated: 2021/12/16

ChemScene

Product number: CS-0027924
Product name: Karacoline
Packaging: 5mg
Price: $457
Updated: 2021/12/16

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KARAKOLINE Chemical Properties,Usage,Production

Description

A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.

Uses

Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Definition

ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.

References

Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)

KARAKOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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39089-30-0, KARAKOLINERelated Search:

ranaconitine Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)- INDACONITINE Aconitine benzoylmesaconine Benzoylhypacoitine CRASSICAULINE A Acetylaconitine Benzoylhypacoitine 12-epi-Napelline benzoylaconine Mesaconitine Hypaconitine VILMORRIANINE C Bullatine B CHASMANINE KARAKOLINE VILMORRIANINE A

(16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol

Karacoline

Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-

Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-

Carmicheline(7CI)

11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.

(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol

Inhibitor,Karacoline,inhibit

Karacoline, 10 mM in DMSO

39089-30-0

Alkaloids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract