KARAKOLINE
- Product Name
- KARAKOLINE
- CAS No.
- 39089-30-0
- Chemical Name
- KARAKOLINE
- Synonyms
- Karacoline;Carmicheline(7CI);Inhibitor,Karacoline,inhibit;(16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol;(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol;Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-;Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-;11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.
- CBNumber
- CB3986952
- Molecular Formula
- C22H35NO4
- Formula Weight
- 377.52
- MOL File
- 39089-30-0.mol
KARAKOLINE Property
- Melting point:
- 185-186℃ (acetone )
- Boiling point:
- 540.2±50.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- pka
- 13.80±0.70(Predicted)
Safety
- RTECS
- AR5569480
N-Bromosuccinimide Price
- Product number
- K139700
- Product name
- Karacoline
- Packaging
- 1mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- K139700
- Product name
- Karacoline
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- N2030
- Product name
- Karacoline
- Packaging
- 20mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-0027924
- Product name
- Karacoline
- Packaging
- 10mg
- Price
- $743
- Updated
- 2021/12/16
- Product number
- CS-0027924
- Product name
- Karacoline
- Packaging
- 5mg
- Price
- $457
- Updated
- 2021/12/16
KARAKOLINE Chemical Properties,Usage,Production
Description
A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.
Uses
Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
Definition
ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.
References
Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)