ChemicalBook > CAS DataBase List > 1-Phenoxy-2-propanol

1-Phenoxy-2-propanol

Product Name
1-Phenoxy-2-propanol
CAS No.
770-35-4
Chemical Name
1-Phenoxy-2-propanol
Synonyms
PROPYLENE GLYCOL PHENYL ETHER;1-PHENOXYPROPAN-2-OL;Phenoxyisopropanol;DOWANOL®DOWANOL? PPh;AURORA KA-7000;1-Phenoxy-2-pr;DOWANOL(TM) PPH;PHENOXY PROPANOL;1-phenoxy-2-propano
CBNumber
CB4100744
Molecular Formula
C9H12O2
Formula Weight
152.19
MOL File
770-35-4.mol
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1-Phenoxy-2-propanol Property

Melting point:
11 °C
Boiling point:
243 °C (lit.)
Density 
1.064 g/mL at 20 °C (lit.)
vapor pressure 
1Pa at 20℃
refractive index 
n20/D 1.523(lit.)
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
water: soluble15.1g/L at 20°C
form 
Oil
pka
14.43±0.20(Predicted)
color 
Clear Colourless
Specific Gravity
1.051
Water Solubility 
15.1g/L at 20℃
BRN 
1941356
Stability:
Stable. Flammable. Incompatible with strong oxidizing agents.
LogP
1.41 at 24.1℃
CAS DataBase Reference
770-35-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Phenoxy-2-propanol(770-35-4)
EPA Substance Registry System
1-Phenoxy-2-propanol (770-35-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
23-26
WGK Germany 
1
RTECS 
UB8886500
TSCA 
Yes
HS Code 
29094990
Hazardous Substances Data
770-35-4(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 2830 mg/kg NTIS** OTS0539745
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
484423
Product name
1-Phenoxy-2-propanol
Purity
≥93%
Packaging
1l
Price
$66.4
Updated
2024/03/01
TCI Chemical
Product number
P0118
Product name
1-Phenoxy-2-propanol
Purity
>95.0%(GC)
Packaging
25mL
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
P0118
Product name
1-Phenoxy-2-propanol
Purity
>95.0%(GC)
Packaging
500mL
Price
$1155
Updated
2024/03/01
Alfa Aesar
Product number
L04596
Product name
1-Phenoxy-2-propanol, tech. 85%
Packaging
50g
Price
$33.65
Updated
2024/03/01
Alfa Aesar
Product number
L04596
Product name
1-Phenoxy-2-propanol, tech. 85%
Packaging
250g
Price
$128
Updated
2024/03/01
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1-Phenoxy-2-propanol Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

1-Phenoxy-2-propanol is a useful synthetic intermediate. It was used in the preparation of acylarylthiocarbamates as nonnucleoside reverse transcriptase inhibitors.

Uses

High-boiling solvent, bactericidal agent, fixa- tive for soaps and perfumes, intermediate for plas- ticizers.

Definition

Colorless liquid.Combustible.

Application

1-Phenoxy-2-propanol (PP) is used as a preservative in cosmetics. PP is currently permitted for up to 1% in cosmetic formulations in Korea and Europe. In addition to its cosmetic uses, PP is used as a solvent for mixing water and organic components in paints, coatings, and films. It is used as an ink solvent for industrial paints, ballpoint pens, stamp pads, and paint removers. The exposure range is broad since PP is used in various industrial paints and cosmetic

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 9357, 1995 DOI: 10.1016/0040-4039(95)02027-M

General Description

1-Phenoxy-2-propanol (PP), a gycol ether, can be synthesized by reacting propylene oxide with phenol in the presence of Al2O3-MgO/Fe3O4 catalyst. The influence of its anesthetic property on gastropods has been analyzed. Its degradation by microorganisms in different soil types has been investigated.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion and skin contact. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.

Toxicity evaluation

1-Phenoxy-2-propanol (PP) does not cause skin irritation or sensitization. However, it may induce mucosal irritation. The pregnant Himalayan rabbits were orally administered 0, 60, 180, and 540?mg/kg/day of PP during organogenesis (7–19 days of pregnancy). LOAEL (Lowest Observed Adverse Effect Level) for maternal toxicity was assessed at 540?mg/kg/day based on weight loss and apathy. In addition, LOAEL for developmental toxicity was 540?mg/kg/day, and NOAEL (No Observed Adverse Effect Level) was assessed at 180?mg/kg/day. The other study reported that NOAEL for maternal toxicity of PP orally treated to pregnant Wistar rats was 40?mg/kg/day, and NOAEL for developmental toxicity of PP was 160?mg/kg/day.

Regulations

1-Phenoxy-2-propanol (PP) has antibacterial properties and is designated as a sterilizing and preserving agent used in cosmetics and soaps. In Korea, PP comprises up to 1.0% of formulations and is only allowed in products that are washed off after use, and other products are prohibited. European Commission (EC) restricts washing products to 1.0% or less[1].

References

[1] Jung Dae Lee . “Percutaneous permeability of 1-phenoxy-2-propanol, a preservative in cosmetics.” Regulatory Toxicology and Pharmacology 103 (2019): Pages 56-62.

1-Phenoxy-2-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Phenoxy-2-propanol Suppliers

Americas 1 Australia 1 Austria 1 China 202 Europe 3 France 1 Germany 8 India 9 Italy 2 Japan 5 Philippines 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 30 USA 1 Global 276
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View Lastest Price from 1-Phenoxy-2-propanol manufacturers

Jinan Finer Chemical Co., Ltd
Product
1-Phenoxy-2-propanol 770-35-4
Price
US $2.00/KG
Min. Order
1KG
Purity
≥99%
Supply Ability
1000mt/year
Release date
2022-10-11
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1-Phenoxy-2-propanol 770-35-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-15
hebei hongtan Biotechnology Co., Ltd
Product
1-Phenoxy-2-propanol 770-35-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-22

770-35-4, 1-Phenoxy-2-propanolRelated Search:

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