2-CYANO-5-HYDROXYMETHYLPYRIDINE
- Product Name
- 2-CYANO-5-HYDROXYMETHYLPYRIDINE
- CAS No.
- 58553-48-3
- Chemical Name
- 2-CYANO-5-HYDROXYMETHYLPYRIDINE
- Synonyms
- 5-(hydroxyMethyl)picolinonitrile;5-(HydroxyMethyl)pyridine-2-carbonitrile;5-(hydroxyMethyl)-2-Pyridinecarbonitrile;2-Pyridinecarbonitrile, 5-(hydroxymethyl)-
- CBNumber
- CB41010071
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 58553-48-3.mol
2-CYANO-5-HYDROXYMETHYLPYRIDINE Property
- Melting point:
- 78-79 °C(Solv: benzene (71-43-2))
- Boiling point:
- 353.8±32.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- 13.26±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H972640
- Product name
- 5-(Hydroxymethyl)pyridine-2-carbonitrile
- Packaging
- 50mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- OR300195
- Product name
- 5-(Hydroxymethyl)pyridine-2-carbonitrile
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H37-1-2F
- Product name
- 5-(Hydroxymethyl)pyridine-2-carbonitrile
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- OR300195
- Product name
- 5-(Hydroxymethyl)pyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $283
- Updated
- 2021/12/16
- Product number
- 4H37-1-2F
- Product name
- 5-(Hydroxymethyl)pyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $312
- Updated
- 2021/12/16
2-CYANO-5-HYDROXYMETHYLPYRIDINE Chemical Properties,Usage,Production
Synthesis
1620-77-5
58553-48-3
General procedure for the synthesis of 2-cyano-5-hydroxymethylpyridine from 2-cyano-5-methylpyridine: 2-cyano-5-methylpyridine (13 g, 110 mmol) was dissolved in 400 mL of carbon tetrachloride, N-bromosuccinimide (29.4 g, 165 mmol) and dibenzoyl peroxide (0.4 g, 1.6 mmol) were added. The reaction mixture was heated to reflux for 3 h, followed by cooling to room temperature and filtration. The filtrate was washed with aqueous sodium thiosulfate, dried over anhydrous magnesium sulfate and subsequently concentrated under vacuum to remove the solvent. The residue was dissolved in a solvent mixture of 200 mL of dioxane and 200 mL of water, calcium carbonate (44 g, 440 mmol) was added and the mixture was stirred under reflux conditions for 2 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was filtered and dichloromethane was added to the filtrate. After separation of the organic phase, it was dried with anhydrous magnesium sulfate and concentrated in vacuum to remove the solvent. Finally, the target product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, 2:1). Yield: 5.2 g (35%). The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ=4.7 (d, 2H); 5.6 (t, 1H); 8.0 (m, 2H); 8.7 (s, 1H) ppm.
References
[1] Patent: WO2004/20410, 2004, A2. Location in patent: Page 81-82
[2] Patent: WO2004/24700, 2004, A1. Location in patent: Page 37
[3] Patent: WO2005/82863, 2005, A2. Location in patent: Page/Page column 29
2-CYANO-5-HYDROXYMETHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CYANO-5-HYDROXYMETHYLPYRIDINE Suppliers
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 0515-89701588 13770166955
- Fax
- 0515-87400189
- orgunion@orgunion.com
- Country
- China
- ProdList
- 620
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 021-18721936-595 18721936595
- Fax
- -
- shkylpharma@126.com
- Country
- China
- ProdList
- 734
- Advantage
- 55
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 13162380607
- Fax
- QQ:1696175688
- 1696175688@qq.com
- Country
- China
- ProdList
- 817
- Advantage
- 55
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7992
- Advantage
- 55
- Tel
- 13812573443
- Fax
- -
- tongbenwan22@163.com
- Country
- China
- ProdList
- 1980
- Advantage
- 55