3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
- Product Name
- 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
- CAS No.
- 1666-04-2
- Chemical Name
- 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
- Synonyms
- 3,6-Dimethylsalicylaldehyde;3,6-Dimethylsalicylaldehyde>3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE;Benzaldehyde, 2-hydroxy-3,6-dimethyl-;3,6-Dimethyl-2-formylphenol, 2-Formyl-3-hydroxy-p-xylene, 3,6-Dimethylsalicylaldehyde
- CBNumber
- CB41010273
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 1666-04-2.mol
3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Property
- Melting point:
- 59.0 to 63.0 °C
- Boiling point:
- 230.1±35.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.63±0.15(Predicted)
- color
- White to Light yellow to Light orange
Safety
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D4507
- Product name
- 3,6-Dimethylsalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $180
- Updated
- 2025/07/31
- Product number
- D4507
- Product name
- 3,6-Dimethylsalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $599
- Updated
- 2025/07/31
- Product number
- H824985
- Product name
- 2-Hydroxy-3,6-dimethylbenzaldehyde
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H824985
- Product name
- 2-Hydroxy-3,6-dimethylbenzaldehyde
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- H824985
- Product name
- 2-Hydroxy-3,6-dimethylbenzaldehyde
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Hydroxy-3,6-dimethylbenzaldehyde
Synthesis
95-87-4
50-00-0
1666-04-2
To a solution of 2,5-dimethylphenol (7.0 g, 57.3 mmol) in acetonitrile (250 mL) was sequentially added triethylamine (30.1 mL, 0.212 mol) and magnesium chloride (8.17 g, 86 mmol). The reaction mixture was stirred at room temperature for 15 minutes before adding paraformaldehyde (11.5 g, 0.38 mol). Subsequently, the mixture was heated to 80 °C and kept for 20 hours. After completion of the reaction, acetonitrile was removed by distillation under reduced pressure. A 10% hydrochloric acid solution was added to the residue and stirred for 30 min at room temperature. The mixture was extracted with dichloromethane (2 x 40 mL), the organic layers were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting crude product was purified by fast column chromatography on silica gel (eluent: dichloromethane) to afford the target product 3,6-dimethyl-2-hydroxybenzaldehyde (27a) (3.56 g, 23.7 mmol, 42% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.21 (s, 3H), 2.57 (s, 3H), 6.62 (d, J = 8.0 Hz, 1H), 7.24 (d, J = 8.0 Hz, 1H), 10.30 (s, 1H), 12.18 (s, 1H).
References
[1] Journal of Organometallic Chemistry, 2005, vol. 690, # 23, p. 5125 - 5144
[2] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584
[3] Patent: WO2012/140243, 2012, A1. Location in patent: Page/Page column 137-138
[4] Journal of Organic Chemistry, 2013, vol. 78, # 14, p. 6890 - 6910
[5] Patent: US2016/152543, 2016, A1. Location in patent: Paragraph 1197; 1198; 1199
3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE manufacturers
- Product
- 2-Hydroxy-3,6-dimethylbenzaldehyde 1666-04-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-23
- Product
- 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE 1666-04-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 200KG
- Release date
- 2020-01-07