NEOTROFIN

Product Name: NEOTROFIN
CAS No.: 192564-13-9
Chemical Name: NEOTROFIN
Synonyms: SPI205;SPI-205;SPI 205;NEOTROFIN;Leteprinim potassium;Leteprinim Potassium Salt;Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate;4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid;4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt;Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1)
CBNumber: CB41011492
Molecular Formula: C15H12N5O4.K
Formula Weight: 365.389
MOL File: 192564-13-9.mol

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NEOTROFIN Property

Melting point:: 268-270°C (dec.)
storage temp.: Refrigerator
solubility: Water
form: Solid
color: Off White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21748
Product name: Leteprinim (potassium salt)
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 21748
Product name: Leteprinim (potassium salt)
Packaging: 5mg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 21748
Product name: Leteprinim (potassium salt)
Packaging: 10mg
Price: $263
Updated: 2024/03/01

Usbiological

Product number: 015530
Product name: Leteprinim Potassium Salt
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: L329900
Product name: LeteprinimPotassiumSalt
Packaging: 100mg
Price: $875
Updated: 2021/12/16

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NEOTROFIN Chemical Properties,Usage,Production

Chemical Properties

Off White to Pale Yellow Solid

Uses

A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism.

brand name

Neotrofin (NeoTherapeutics).

in vivo

Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons^[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice^[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups^[4].

Animal Model:	Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)^[4]
Dosage:	60 mg/kg
Administration:	IP; single dosage
Result:	The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group. In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.

NEOTROFIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NEOTROFIN Suppliers

Canada 1 CHINA 21 India 1 United States 6 Global 29

J & K SCIENTIFIC LTD.

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Spectrum Chemical Manufacturing Corp.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Energy Chemical

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Cayman Chemical Company

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192564-13-9, NEOTROFINRelated Search:

NEOTROFIN AIT 082 P-AMINOBENZOIC ACID POTASSIUM SALT

4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid

NEOTROFIN

4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt

Leteprinim Potassium Salt

Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate

Leteprinim potassium

SPI 205

SPI205

SPI-205

Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1)

192564-13-9

C15H12KN5O4

Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals