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NEOTROFIN

Product Name
NEOTROFIN
CAS No.
192564-13-9
Chemical Name
NEOTROFIN
Synonyms
SPI205;SPI-205;SPI 205;NEOTROFIN;Leteprinim potassium;Leteprinim Potassium Salt;Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate;4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid;4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt;Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1)
CBNumber
CB41011492
Molecular Formula
C15H12N5O4.K
Formula Weight
365.389
MOL File
192564-13-9.mol
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NEOTROFIN Property

Melting point:
268-270°C (dec.)
storage temp. 
Refrigerator
solubility 
Water
form 
Solid
color 
Off White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21748
Product name
Leteprinim (potassium salt)
Packaging
1mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
21748
Product name
Leteprinim (potassium salt)
Packaging
5mg
Price
$162
Updated
2024/03/01
Cayman Chemical
Product number
21748
Product name
Leteprinim (potassium salt)
Packaging
10mg
Price
$263
Updated
2024/03/01
Usbiological
Product number
015530
Product name
Leteprinim Potassium Salt
Packaging
10mg
Price
$403
Updated
2021/12/16
TRC
Product number
L329900
Product name
LeteprinimPotassiumSalt
Packaging
100mg
Price
$875
Updated
2021/12/16
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NEOTROFIN Chemical Properties,Usage,Production

Chemical Properties

Off White to Pale Yellow Solid

Uses

A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism.

brand name

Neotrofin (NeoTherapeutics).

in vivo

Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].

Animal Model:Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4]
Dosage:60 mg/kg
Administration:IP; single dosage
Result:The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.

NEOTROFIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NEOTROFIN Suppliers

Canada 1 CHINA 21 India 1 United States 6 Global 29
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

192564-13-9, NEOTROFINRelated Search:

NEOTROFIN AIT 082 P-AMINOBENZOIC ACID POTASSIUM SALT

  • 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid
  • NEOTROFIN
  • 4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt
  • Leteprinim Potassium Salt
  • Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate
  • Leteprinim potassium
  • SPI 205
  • SPI205
  • SPI-205
  • Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1)
  • 192564-13-9
  • C15H12KN5O4
  • Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals