Atibuclimab

Product Name: Atibuclimab
CAS No.: 2417175-94-9
Chemical Name: Atibuclimab
Synonyms: Atibuclimab;Atibuclimab (anti-CD14);Research Grade Atibuclimab;Research Grade Atibuclimab(DHC33701)
CBNumber: CB410616927
Formula Weight: 0
MOL File: Mol file

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Atibuclimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Atibuclimab Chemical Properties,Usage,Production

Uses

Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis[1]. Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist[2].

References

[1] Henderson RD, Agosti JM, McCombe PA, et al. Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis. Medicine (Baltimore). 2021;100(42):e27421. DOI:10.1097/MD.0000000000027421
[2] Verbon A, et al. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J Immunol. 2001;166(5):3599-3605. DOI:10.4049/jimmunol.166.5.3599

Atibuclimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Atibuclimab Suppliers

China 13 United States 1 Global 14

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2417175-94-9, AtibuclimabRelated Search:

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Atibuclimab

Research Grade Atibuclimab(DHC33701)

Research Grade Atibuclimab

Atibuclimab (anti-CD14)

2417175-94-9