Mipasetamab

Product Name: Mipasetamab
CAS No.: 2361055-48-1
Chemical Name: Mipasetamab
Synonyms: Mipasetamab;Mipasetamab (anti-AXL);Research Grade Mipasetamab;Research Grade Mipasetamab (DHD89503)
CBNumber: CB410617050
Formula Weight: 0
MOL File: Mol file

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Mipasetamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Mipasetamab Chemical Properties,Usage,Production

Uses

Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor. Mipasetamab involves in synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC). ADCT-601 has anti-tumor activity[1].

in vivo

ADCT-601 (3 mg/kg, 6 mg/kg; i.v.; single dose) is safety and tolerability in non-tumor-bearing male Sprague-Dawley rats^[1].
ADCT-601 (1 mg/kg; i.v.; once daily for 60 days) shows potent and sustained antitumor activity for mouse in both MDA-MB-231 TNBC xenograft model and SN12C renal cancer xenograft model^[1].
ADCT-601 (0.075, 0.15, or 0.3 mg/kg; i.v.; once daily for 45 days) also dose-dependently in a pancreatic cancer PDX model (PAXF1657) with heterogeneous AXL expression^[1].

Animal Model:	Mouse model with SN12C renal cancer xenograft or MDA-MB-231 TNBC xenograft^[1]
Dosage:	0.3, 0.6, and 1 mg/kg
Administration:	Intravenous injection; once daily for 60 days
Result:	Significantly inhibited the growth of tumor volume in vivo in mouse.

IC 50

Axl

References

[1] Zammarchi F, et al. Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers. Mol Cancer Ther. 2022 Apr 1;21(4):582-593. DOI:10.1158/1535-7163.MCT-21-0715

Mipasetamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Mipasetamab Suppliers

China 9 Global 9

Shanghai YuanYe Biotechnology Co., Ltd.

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Cell Sciences

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Mipasetamab

Research Grade Mipasetamab (DHD89503)

Research Grade Mipasetamab

Mipasetamab (anti-AXL)

2361055-48-1