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NEUROPEPTIDE S (HUMAN)

Product Name
NEUROPEPTIDE S (HUMAN)
CAS No.
412938-67-1
Chemical Name
NEUROPEPTIDE S (HUMAN)
Synonyms
NPS (HUMAN);SFRNGVGTGMKKTSFQRAKS;NEUROPEPTIDE S (HUMAN);Neuropeptide S, NPS, human;Neuropeptide S (huMan) NPS (huMan);SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER;H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH;REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH;L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-
CBNumber
CB4106928
Molecular Formula
C93H155N31O28S
Formula Weight
2187.48
MOL File
412938-67-1.mol
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NEUROPEPTIDE S (HUMAN) Property

Density 
1.49±0.1 g/cm3(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66262
Product name
Neuropeptide S, human
Packaging
0.2mg
Price
$111
Updated
2021/12/16
Alfa Aesar
Product number
J66262
Product name
Neuropeptide S, human
Packaging
0.5mg
Price
$201
Updated
2021/12/16
Alfa Aesar
Product number
J66262
Product name
Neuropeptide S, human
Packaging
1mg
Price
$301
Updated
2021/12/16
Usbiological
Product number
302078
Product name
Neuropeptide S, Human
Packaging
100ug
Price
$372
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0003707
Product name
NEUROPEPTIDE S, HUMAN
Purity
95.00%
Packaging
0.5MG
Price
$676.83
Updated
2021/12/16
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NEUROPEPTIDE S (HUMAN) Chemical Properties,Usage,Production

Biological Activity

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

in vitro

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC 50 of 6.7 ± 2.4 nM, the binding of [ 125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ 125I I] Y10-NPS, [ 125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC 50 = 0.42 ± 0.12 nM).

in vivo

Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

Animal Model: Male C57Bl/6 mice
Dosage: 0.1 nM, 1 nM
Administration: Intracerebroventricular (icv) injection
Result: Increased locomotor activity and promoted wakefulness.

target

EC50: 9.4 nM (neuropeptide S receptor)

NEUROPEPTIDE S (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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NEUROPEPTIDE S (HUMAN) Suppliers

China 40 Japan 1 United Kingdom 1 United States 7 USA 1 Global 50
Tocris Bioscience
Tel
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Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

412938-67-1, NEUROPEPTIDE S (HUMAN)Related Search:

ALPHA-MSH H-SER-PHE-ARG-ASN-GLY-VAL-GLY-SER-GLY-VAL-LYS-LYS-THR-SER-PHE-ARG-ARG-ALA-LYS-GLN-OH PubChem ID: 54581309 DEMETON S NEUROPEPTIDE S (HUMAN)

  • SFRNGVGTGMKKTSFQRAKS
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  • NPS (HUMAN)
  • NEUROPEPTIDE S (HUMAN)
  • H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH
  • REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH
  • Neuropeptide S, NPS, human
  • Neuropeptide S (huMan) NPS (huMan)
  • L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-
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