Ranitidinebismuthcitrate
- Product Name
- Ranitidinebismuthcitrate
- CAS No.
- 128345-62-0
- Chemical Name
- Ranitidinebismuthcitrate
- Synonyms
- Pylorid;Gastrimuto;Ranitidine bismutrex;RANTIDINEBISMUTHCITRATE;TIANFU CHEM-- Ranitidinebismuthcitrate;2-Hydroxy-1,2,3-propanetricarboxylic acid bismuth(3+) salt compd with N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine
- CBNumber
- CB41073641
- Molecular Formula
- C19H30N4O10S
- Formula Weight
- 506.53
- MOL File
- 128345-62-0.mol
N-Bromosuccinimide Price
- Product number
- API0009220
- Product name
- RANITIDINE BISMUTH CITRATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.82
- Updated
- 2021/12/16
- Product number
- 2622
- Product name
- Ranitidine bismuth citrate
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
Ranitidinebismuthcitrate Chemical Properties,Usage,Production
Description
Ranitidine bismuth citrate, a novel salt formed from ranitidine and a bismuth citrate complex, is a new agent introduced in the United Kingdom for the treatment of duodenal and benign gastric ulcers, for eradication of Helicobacfer pylori, and for prevention of relapse of duodenal ulcer when administered in combination with an antibiotic such as clarithromycin or amoxicillin. Ranitidine is a potent histamine H2-receptor antagonist with ability to inhibit gastric acid secretion. Other type of agents such as tripotassium dicitrato bismuthate exert their therapeutic effects in peptic ulceration by providing a protective coating to the ulcer crater, stimulating endogenous prostaglandin production, and inhibiting pepsin activity. More significantly, they inhibit micro-organism Helicobacfer pylori, a prevalent, specifically human pathogen associated with gastritis and gastric ulcers. The title compound possesses a novel combination of properties of the above two types of drugs and displays excellent therapeutic efficacy in clinical studies. Ranitidine bismuth citrate is being investigated for use in gastritis and non-ulcerating dyspepsia, acute healing of gastrointestinal ulcer and in prevention of the recurrence of peptic ulcer disease.
Originator
Glaxo Wellcome (United Kingdom)
Uses
Antagonist (to histamine H2receptors).
brand name
Tritec (GlaxoSmithKline);Pylorid.
Hazard
A poison by ingestion.
Mechanism of action
Ranitidine bismuth citrate has been developed for combination therapy with antibiotics for eradication of H.p. Depending on the co-prescription, eradication ranged from 15 to 92 % in an intention-to-treat analysis . It is claimed to combine the antisecretory action of ranitidine with the antimicrobial and gastroprotective actions of bismuth.
Ranitidinebismuthcitrate Preparation Products And Raw materials
Raw materials
Preparation Products
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- Product
- Ranitidinebismuthcitrate 128345-62-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-28