5,5-Dimethyl-2-pyrrolidinone

Product Name: 5,5-Dimethyl-2-pyrrolidinone
CAS No.: 5165-28-6
Chemical Name: 5,5-Dimethyl-2-pyrrolidinone
Synonyms: 5,5-Dimethyl-2-pyrrolidone;2-Pyrrolidinone,5,5-dimethyl-;5,5-DiMethylpyrrolidine-2-one
CBNumber: CB41073939
Molecular Formula: C6H11NO
Formula Weight: 113.16
MOL File: 5165-28-6.mol

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5,5-Dimethyl-2-pyrrolidinone Property

Melting point:: 39-40℃
Boiling point:: 85℃ (0.4 Torr)
Density: 0.945±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: low melting solid
pka: 16.74±0.40(Predicted)
color: White

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: D468135
Product name: 5,5-Dimethyl-2-pyrrolidone
Packaging: 100mg
Price: $50
Updated: 2021/12/16

TRC

Product number: D468135
Product name: 5,5-Dimethyl-2-pyrrolidone
Packaging: 500mg
Price: $140
Updated: 2021/12/16

TRC

Product number: D468135
Product name: 5,5-Dimethyl-2-pyrrolidone
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD116611
Product name: 5,5-Dimethylpyrrolidin-2-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR929277
Product name: 5,5-Dimethylpyrrolidin-2-one
Purity: 95%
Packaging: 1g
Price: $130
Updated: 2021/12/16

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5,5-Dimethyl-2-pyrrolidinone Chemical Properties,Usage,Production

Uses

5,5-Dimethyl-2-pyrrolidone, is a versatile building block used in the synthesis of various chemical compounds, such as novel, Induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

Synthesis

16507-02-1

5165-28-6

General procedure for the synthesis of 5,5-dimethyl-2-pyrrolidinone from methyl 4-methyl-4-nitrovalerate: synthesis of compound 218.2. Sodium borohydride (0.717 g, 11.428 mmol, 2.0 eq.) was slowly added to a methanol (10 mL) solution of nickel chloride (2.291 g, 11.428 mmol, 2.0 eq.), and the reaction mixture was stirred for 30 min at room temperature. Subsequently, methyl 4-methyl-4-nitrovalerate (1.0 g, 5.714 mmol, 1.0 eq.) was added dropwise to the above reaction mixture and stirring was continued at room temperature for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and water was added to the residue. The aqueous phase was extracted with ethyl acetate, the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography to afford the target compound 218.2 (0.250 g, 38.70% yield), mass spectrum (electrospray ionization): m/z 113.16 [M + H]+.

References

[1] Chemical Communications, 2012, vol. 48, # 84, p. 10440 - 10442
[2] Tetrahedron Letters, 1985, vol. 26, # 52, p. 6413 - 6416
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 001135; 001136
[4] Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 53 - 57
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 407,412

5,5-Dimethyl-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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5,5-Dimethyl-2-pyrrolidinone Suppliers

China 67 Germany 1 India 2 United Kingdom 1 United States 7 Global 78

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View Lastest Price from 5,5-Dimethyl-2-pyrrolidinone manufacturers

Career Henan Chemical Co

Product: 5,5-Dimethyl-2-pyrrolidinone 5165-28-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 741
Release date: 2019-09-01

5165-28-6, 5,5-Dimethyl-2-pyrrolidinoneRelated Search:

CLASTO-LACTACYSTIN LACTACYSTIN (+)-LACTACYSTIN ALLYL ESTER 5,5-Dimethyl-2-pyrrolidinone (S)-2-(2-PROPENYL)-2-CARBOXY-5-OXO-PYRROLIDINE (3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE (3R,4S,5S,6S)-1-AZA-5-CARBOXYL-4-HYDROXY-6-ISOPROPYL-3-METHYL-7-OXABICYCLO[3.3.0]OCTAN-2-ONE CLASTO-LACTACYSTIN BETA-LACTONE (3R,4S,5R)-4-HYDROXY-5-[(1S)-1-HYDROXY-2-METHYLPROPYL]-3-METHYL-2-PYRROLIDINONE-5-CARBOXYLIC ACID 1-BENZYL-5-(4-CHLOROBENZOYL)-5-METHYLPYRROLIDIN-2-ONE 5-METHYL-5-[4-(TRIFLUOROMETHYL)BENZOYL]-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDIN-2-ONE 5-METHYL-5-[4-(4-MORPHOLINYL)BENZOYL]-1-(1-NAPHTHYLMETHYL)-2-PYRROLIDINONE ALPHA-METHYL CLASTO-LACTACYSTIN BETA-LACTONE 5-(4-BROMOBENZOYL)-5-METHYL-1-(3,4,5-TRIMETHOXYBENZYL)-2-PYRROLIDINONE (3R,4S,5S,6S)-1-AZA-5-(T-BUTYLDIMETHYLSILYLOXYMETHYL)-4-HYDROXY-6-ISOPROPYL-3-METHYL-7-OXABICYCLO[3.3.0]-OCTAN-2-ONE 5-(4-CHLOROBENZOYL)-5-METHYL-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDIN-2-ONE TIMTEC-BB SBB001021 11B-METHYL-3-OXO-2,3,5,6,11,11B-HEXAHYDRO-1H-INDOLIZINO[8,7-B]INDOLE-5-CARBOXYLIC ACID

5,5-Dimethyl-2-pyrrolidone

5,5-DiMethylpyrrolidine-2-one

2-Pyrrolidinone,5,5-dimethyl-

5165-28-6