ChemicalBook > CAS DataBase List > 5,5-Dimethyl-2-pyrrolidinone

5,5-Dimethyl-2-pyrrolidinone

Product Name
5,5-Dimethyl-2-pyrrolidinone
CAS No.
5165-28-6
Chemical Name
5,5-Dimethyl-2-pyrrolidinone
Synonyms
5,5-Dimethyl-2-pyrrolidone;2-Pyrrolidinone,5,5-dimethyl-;5,5-DiMethylpyrrolidine-2-one
CBNumber
CB41073939
Molecular Formula
C6H11NO
Formula Weight
113.16
MOL File
5165-28-6.mol
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5,5-Dimethyl-2-pyrrolidinone Property

Melting point:
39-40℃
Boiling point:
85℃ (0.4 Torr)
Density 
0.945±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
low melting solid
pka
16.74±0.40(Predicted)
color 
White
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
D468135
Product name
5,5-Dimethyl-2-pyrrolidone
Packaging
100mg
Price
$50
Updated
2021/12/16
TRC
Product number
D468135
Product name
5,5-Dimethyl-2-pyrrolidone
Packaging
250mg
Price
$90
Updated
2021/12/16
TRC
Product number
D468135
Product name
5,5-Dimethyl-2-pyrrolidone
Packaging
500mg
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
037074
Product name
5,5-Dimethylpyrrolidin-2-one
Packaging
500mg
Price
$54
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD116611
Product name
5,5-Dimethylpyrrolidin-2-one
Packaging
250mg
Price
$57.5
Updated
2021/12/16
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5,5-Dimethyl-2-pyrrolidinone Chemical Properties,Usage,Production

Uses

5,5-Dimethyl-2-pyrrolidone, is a versatile building block used in the synthesis of various chemical compounds, such as novel, Induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

Synthesis

16507-02-1

5165-28-6

General procedure for the synthesis of 5,5-dimethyl-2-pyrrolidinone from methyl 4-methyl-4-nitrovalerate: synthesis of compound 218.2. Sodium borohydride (0.717 g, 11.428 mmol, 2.0 eq.) was slowly added to a methanol (10 mL) solution of nickel chloride (2.291 g, 11.428 mmol, 2.0 eq.), and the reaction mixture was stirred for 30 min at room temperature. Subsequently, methyl 4-methyl-4-nitrovalerate (1.0 g, 5.714 mmol, 1.0 eq.) was added dropwise to the above reaction mixture and stirring was continued at room temperature for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and water was added to the residue. The aqueous phase was extracted with ethyl acetate, the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography to afford the target compound 218.2 (0.250 g, 38.70% yield), mass spectrum (electrospray ionization): m/z 113.16 [M + H]+.

References

[1] Chemical Communications, 2012, vol. 48, # 84, p. 10440 - 10442
[2] Tetrahedron Letters, 1985, vol. 26, # 52, p. 6413 - 6416
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 001135; 001136
[4] Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 53 - 57
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 407,412

5,5-Dimethyl-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,5-Dimethyl-2-pyrrolidinone manufacturers

Career Henan Chemical Co
Product
5,5-Dimethyl-2-pyrrolidinone 5165-28-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 741
Release date
2019-09-01

5165-28-6, 5,5-Dimethyl-2-pyrrolidinoneRelated Search:

CLASTO-LACTACYSTIN LACTACYSTIN (+)-LACTACYSTIN ALLYL ESTER 5,5-Dimethyl-2-pyrrolidinone (S)-2-(2-PROPENYL)-2-CARBOXY-5-OXO-PYRROLIDINE (3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE (3R,4S,5S,6S)-1-AZA-5-CARBOXYL-4-HYDROXY-6-ISOPROPYL-3-METHYL-7-OXABICYCLO[3.3.0]OCTAN-2-ONE CLASTO-LACTACYSTIN BETA-LACTONE (3R,4S,5R)-4-HYDROXY-5-[(1S)-1-HYDROXY-2-METHYLPROPYL]-3-METHYL-2-PYRROLIDINONE-5-CARBOXYLIC ACID 1-BENZYL-5-(4-CHLOROBENZOYL)-5-METHYLPYRROLIDIN-2-ONE 5-METHYL-5-[4-(TRIFLUOROMETHYL)BENZOYL]-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDIN-2-ONE 5-METHYL-5-[4-(4-MORPHOLINYL)BENZOYL]-1-(1-NAPHTHYLMETHYL)-2-PYRROLIDINONE ALPHA-METHYL CLASTO-LACTACYSTIN BETA-LACTONE 5-(4-BROMOBENZOYL)-5-METHYL-1-(3,4,5-TRIMETHOXYBENZYL)-2-PYRROLIDINONE (3R,4S,5S,6S)-1-AZA-5-(T-BUTYLDIMETHYLSILYLOXYMETHYL)-4-HYDROXY-6-ISOPROPYL-3-METHYL-7-OXABICYCLO[3.3.0]-OCTAN-2-ONE 5-(4-CHLOROBENZOYL)-5-METHYL-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDIN-2-ONE TIMTEC-BB SBB001021 11B-METHYL-3-OXO-2,3,5,6,11,11B-HEXAHYDRO-1H-INDOLIZINO[8,7-B]INDOLE-5-CARBOXYLIC ACID

  • 5,5-Dimethyl-2-pyrrolidone
  • 5,5-DiMethylpyrrolidine-2-one
  • 2-Pyrrolidinone,5,5-dimethyl-
  • 5165-28-6