4-Pyrimidinamine, 2-methyl- (9CI)
- Product Name
- 4-Pyrimidinamine, 2-methyl- (9CI)
- CAS No.
- 74-69-1
- Chemical Name
- 4-Pyrimidinamine, 2-methyl- (9CI)
- Synonyms
- 184573;PKR-00635;2-methylpyrimidin-4-amine;4-PyriMidinaMine,2-Methyl;2-Methyl-4-pyrimidinamine;4-Amino-2-methylpyrimidine;2-Methylpyrimidin-4-amine 98%;4-Pyrimidinamine, 2-methyl- (9CI);2-Methyl-4-Pyrimidinamine(WX606010);2-methyl-1,4-dihydropyrimidin-4-imine
- CBNumber
- CB41081857
- Molecular Formula
- C5H7N3
- Formula Weight
- 109.13
- MOL File
- 74-69-1.mol
4-Pyrimidinamine, 2-methyl- (9CI) Property
- Melting point:
- 204-205℃
- Boiling point:
- 222℃
- Density
- 1.155
- Flash point:
- 111℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.99±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H7N3/c1-4-7-3-2-5(6)8-4/h2-3H,1H3,(H2,6,7,8)
- InChIKey
- GKVDLTTVBNOGNJ-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=CC(N)=N1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M336400
- Product name
- 2-methyl-1,4-dihydropyrimidin-4-imine
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- OR301238
- Product name
- 2-Methylpyrimidin-4-amine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- FA45095
- Product name
- 4-Amino-2-methylpyrimidine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 076250
- Product name
- 2-Methyl-4-pyrimidinamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- FA45095
- Product name
- 4-Amino-2-methylpyrimidine
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
4-Pyrimidinamine, 2-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 7, p. 4325, 1966 DOI: 10.1016/0005-2760(66)90119-6
Synthesis
1445-45-0
60838-50-8
74-69-1
The general procedure for the synthesis of 2-methyl-4-aminopyrimidine from trimethyl orthoacetate and 3-methoxyacrylonitrile was as follows: in a 10 mL stainless steel pressure-resistant reactor, 1.0 g (12 mmol) of 3-methoxyacrylonitrile, 3.9 g (32 mmol) of trimethyl orthoacetate, and 4.0 g (56 mmol) of 24 wt% ammonia-methanol solution were added in sequence. The reaction mixture was stirred at 130°C for 8 hours. After completion of the reaction, 20 mL of hexane was added to the reaction mixture, stirred thoroughly and filtered to afford 0.94 g (isolated yield: 72%) of the target product 2-methyl-4-aminopyrimidine as yellow crystals. 2-methyl-4-aminopyrimidine was characterized physically as follows: 1H-NMR (DMSO-d6, δ/ppm): 2.29 (3H, s), 6.22 (1H, dd, J = 5.9), 4.0 g (56 mmol) of 24 wt% ammonia-methanol solution. dd, J = 5.9, 0.5 Hz), 6.69 (2H, brs), 7.94 (1H, d, J = 5.9 Hz); CI-MS (m/e): 109 (M + 1).
References
[1] Patent: US2008/45712, 2008, A1. Location in patent: Page/Page column 3-4
4-Pyrimidinamine, 2-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Pyrimidinamine, 2-methyl- (9CI) manufacturers
- Product
- 2-Methyl-4-pyrimidinamine 74-69-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 4-Pyrimidinamine, 2-methyl- (9CI) 74-69-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-13
- Product
- 4-Pyrimidinamine, 2-methyl- (9CI) 74-69-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02