15(S)-HETRE Property

Boiling point:

487.4±40.0 °C(Predicted)

Density 

0.971±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

pka

4.77±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

15(S)-HETRE Chemical Properties,Usage,Production

Description

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid (DGLA; ). It is an inhibitor of 5-LO in human PMNL with an IC₅₀ value of 4.6 μM.¹ In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.²

References

1. Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action Biochem. J. 314,911-916(1996).
2. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues J. Med. Chem. 30(2),254-263(1987).