ChemicalBook > CAS DataBase List > Dimethylenastron

Dimethylenastron

Product Name
Dimethylenastron
CAS No.
863774-58-7
Chemical Name
Dimethylenastron
Synonyms
enastron;Dimethylenastron;Eg5 Inhibitor III;Eg5 Inhibitor III(Dimethylenastron);Dimethylenastron - Eg5 inhibitor III;Inhibitor,Dimethylenastron,Kinesin,inhibit;Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem;2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone;4-(3-Hydroxyphenyl)-7,7-dimethyl-2-thioxo-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one;5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-
CBNumber
CB41115853
Molecular Formula
C16H18N2O2S
Formula Weight
302.39
MOL File
863774-58-7.mol
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Dimethylenastron Property

Boiling point:
475.6±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
pka
9.59±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H360May damage fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
324622
Product name
Eg5 Inhibitor III, Dimethylenastron
Packaging
5mg
Price
$432
Updated
2024/03/01
Sigma-Aldrich
Product number
324622
Product name
Eg5 Inhibitor III, Dimethylenastron
Packaging
1mg
Price
$154
Updated
2023/01/07
Cayman Chemical
Product number
22357
Product name
Dimethylenastron
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22357
Product name
Dimethylenastron
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0905
Product name
Dimethylenastron
Purity
≥98% (HPLC)
Packaging
5mg
Price
$108
Updated
2022/05/15
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Dimethylenastron Chemical Properties,Usage,Production

Uses

Dimethylnasetron is an inhibitor of mitotic motor kinesin Eg5, triggering apoptosis and upregulates Hsp-70 in human myeloma cells.

Biochem/physiol Actions

Dimethylenastron is specific, reversible inhibitor of the mitotic motor kinesin Eg5. Dimethylenastron inhibits bipolar spindle formation, and inhibits proliferation, migration and invasion of several pancreatic cancer cell lines in cell based assays.

storage

Store at -20°C

Dimethylenastron Preparation Products And Raw materials

Raw materials

Preparation Products

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Dimethylenastron Suppliers

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View Lastest Price from Dimethylenastron manufacturers

Career Henan Chemical Co
Product
Dimethylenastron 863774-58-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

863774-58-7, DimethylenastronRelated Search:

SILICA Phenol Dimethylenastron

  • Dimethylenastron
  • 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
  • Eg5 Inhibitor III(Dimethylenastron)
  • Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem
  • Dimethylenastron - Eg5 inhibitor III
  • Eg5 Inhibitor III
  • enastron
  • 5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-
  • 4-(3-Hydroxyphenyl)-7,7-dimethyl-2-thioxo-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one
  • Inhibitor,Dimethylenastron,Kinesin,inhibit
  • 863774-58-7