4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride
- Product Name
- 4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride
- CAS No.
- 882167-77-3
- Chemical Name
- 4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride
- Synonyms
- 4-Chloro-N-methylpicolinamide Hydrochloride;N-methyl-4-chloro-2-pyridylformamide hydrochloride;4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride;4-Chloro-N-methyl-2-pyridinecarboxamide Hydrochloride;N-Methyl-4-chloro-2-pyridinecarboxamide hydrochloride;4-chloro-N-methylpyridine-2-carboxamide hydrochloride (1:1);2-PyridinecarboxaMide, 4-chloro-N-Methyl-, hydrochloride (1:1);4-Chloropyridine-2-carboxylic Acid Methylamide Monohydrochlorid;4-Chloropyridine-2-carboxylic Acid Methylamide Monohydrochloride
- CBNumber
- CB41175846
- Molecular Formula
- C7H8Cl2N2O
- Formula Weight
- 207.06
- MOL File
- 882167-77-3.mol
4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride Property
- Melting point:
- 144-146°C
- vapor pressure
- 0.093Pa at 20℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Methanol, Water
- form
- Solid
- color
- Pale Yellow
- Water Solubility
- 93g/L at 20℃
- InChI
- InChI=1S/C7H7ClN2O.ClH/c1-9-7(11)6-4-5(8)2-3-10-6;/h2-4H,1H3,(H,9,11);1H
- InChIKey
- XGHILPUCRYAWIN-UHFFFAOYSA-N
- SMILES
- C1(C(=O)NC)=NC=CC(Cl)=C1.Cl
- LogP
- 1.3 at 25℃
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C379955
- Product name
- 4-Chloro-N-methylpyridine-2-carboxamideHydrochloride
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- C379955
- Product name
- 4-Chloro-N-methylpyridine-2-carboxamideHydrochloride
- Packaging
- 5g
- Price
- $685
- Updated
- 2021/12/16
- Product number
- HCH0013174
- Product name
- 4-CHLORO-N-METHYLPYRIDINE-2-CARBOXAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- HCH0013174
- Product name
- 4-CHLORO-N-METHYLPYRIDINE-2-CARBOXAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1732.5
- Updated
- 2021/12/16
- Product number
- FC20300
- Product name
- 4-Chloro-N-methylpyridine-2-carboxamide hydrochloride
- Packaging
- 500g
- Price
- $325
- Updated
- 2021/12/16
4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride (cas# 882167-77-3) is a compound useful in organic synthesis.
Synthesis
220000-87-3
882167-77-3
37% hydrochloric acid (354 g, 3.59 mol) was slowly added to a solution of crude 4-chloro-N-methylpyridine-2-carboxamide (500 g, 2.93 mol) dissolved in acetone (2 kg) under stirring conditions and the temperature of the reaction was controlled not to exceed 40 °C. The reaction mixture was then cooled to about 5 °C and stirred continuously for 1 hour. The product was collected by filtration, washed with acetone (580 g) and subsequently dried under reduced pressure (50 °C, 80 mbar). By this method, 521 g (yield 86% of the theoretical value) of 4-chloro-N-methylpyridine-2-carboxamide hydrochloride was obtained. The melting point of the product was 166-168 °C. 1H NMR (DMSO-d6, 500 MHz) data were as follows: δ= 2.83 (d, J = 4.8 Hz, 3H, NCH3); 3.88 (br.s, HCl/H2O); 7.77 (dd, J = 1.9,5.1 Hz, 1H, 5-H); 8.03 (d, J = 1.6, 1H, 3 -H); 8.63 (d, J = 5.2 Hz, 1H, 6-H); 8.90 (br.s, 1H, NH). Mass spectral analysis (DCI, NH3) showed: m/e = 188 [M + NH4]+, 171 [M + H]+ (M = free base).
References
[1] Patent: WO2006/34796, 2006, A1. Location in patent: Page/Page column 17
4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride manufacturers
- Product
- 4-Chloro-N-methyl pyridine-2-carboxamide hydrochloride 882167-77-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride 882167-77-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27
- Product
- 4-Chloro-N-methylpyridine-2-carboxamide hydrochloride 882167-77-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11