Temozolomideacid
- Product Name
- Temozolomideacid
- CAS No.
- 113942-30-6
- Chemical Name
- Temozolomideacid
- Synonyms
- TMZA;104425;Temozolomideacid;teMozoloMide acid 97%;Temozolomide Impurity C;Temozolomide Impurity 1;TEMOZOLOMIDE ACID; TMZA;Temozolamide Impurity A;Temozolomide EP Impurity B;Temozolamide acid Impurity-B
- CBNumber
- CB41180228
- Molecular Formula
- C6H5N5O3
- Formula Weight
- 195.14
- MOL File
- 113942-30-6.mol
Temozolomideacid Property
- Melting point:
- 166-168°C
- Boiling point:
- 487.7±37.0 °C(Predicted)
- Density
- 1.97±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 2.88±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Safety
- HS Code
- 2933.99.9000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H340May cause genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T3686
- Product name
- Temozolomide Acid
- Packaging
- 50MG
- Price
- $68
- Updated
- 2025/07/31
- Product number
- T3686
- Product name
- Temozolomide Acid
- Packaging
- 250MG
- Price
- $235
- Updated
- 2025/07/31
- Product number
- T017780
- Product name
- Temozolomide Acid
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 021337
- Product name
- Temozolomide Acid
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- SYN5662
- Product name
- Temozolomide Acid
- Packaging
- 100mg
- Price
- $1296
- Updated
- 2021/12/16
Temozolomideacid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A metabolite of Temozolomide (T017775) as antitumor agent.
Synthesis
85622-93-1
113942-30-6
General procedure: Example 1 Preparation of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid (EP0252682) 1. 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (2.577 mmol, 0.5 g) was mixed with concentrated sulfuric acid (4 mL) under stirring conditions. 2. a solution was prepared by dissolving sodium nitrite (9.4 mmol, 0.65 g) in 2.6 mL of water. 3. Slowly add the aqueous sodium nitrite solution dropwise to the above mixture under cooling in an ice bath (keeping the temperature below 15°C). 4. After the dropwise addition, the reaction mixture was stirred at room temperature overnight. 5. 10 g of ice was added to the reaction mixture and cooling was continued in an ice bath for 1 hour. 6. The solid product was collected by filtration. 7. The collected solid product was dried under vacuum to give 0.493 g of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid. The yield was 98.6%.
References
[1] European Journal of Medicinal Chemistry, 2002, vol. 37, # 4, p. 323 - 332
[2] Patent: EP1798234, 2007, A1. Location in patent: Page/Page column 11
[3] Patent: US2018/79754, 2018, A1. Location in patent: Paragraph 0082; 0101-0102
[4] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 691 - 702
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5458 - 5470
Temozolomideacid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Temozolomideacid manufacturers
- Product
- Temozolomideacid 113942-30-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24