Methyl 4-methoxysalicylate
- Product Name
- Methyl 4-methoxysalicylate
- CAS No.
- 5446-02-6
- Chemical Name
- Methyl 4-methoxysalicylate
- Synonyms
- ASISCHEM Z67646;RARECHEM AL BF 0038;4-methoxymethylsalicylate;methyl 2-hydroxy-p-anisate;Methyl P-Methoxysalicylate;METHYL 4-METHOXYSALICYLATE;Methyle4-methoxysalicylate;Methyl4-Methoxysalicylate>4-Methoxysalicylic Acid Methyl;Methyl 4-methoxysalicylate,98%
- CBNumber
- CB4121060
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 5446-02-6.mol
Methyl 4-methoxysalicylate Property
- Melting point:
- 50-53 °C (lit.)
- Boiling point:
- 134°C 7mm
- Density
- 1.1634 (rough estimate)
- refractive index
- 1.4600 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder or Crystals
- pka
- 9.38±0.10(Predicted)
- color
- White to light yellow
- Water Solubility
- Soluble in acetone. Insoluble in water.
- BRN
- 2691644
- InChIKey
- ZICRWXFGZCVTBZ-UHFFFAOYSA-N
- LogP
- 2.430 (est)
- CAS DataBase Reference
- 5446-02-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Methyl 4-methoxysalicylate(5446-02-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 173681
- Product name
- Methyl 4-methoxysalicylate
- Purity
- 98%
- Packaging
- 10g
- Price
- $60.6
- Updated
- 2023/01/07
- Product number
- M1797
- Product name
- Methyl 4-Methoxysalicylate
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- M1797
- Product name
- Methyl 4-Methoxysalicylate
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- M265515
- Product name
- Methyl 4-Methoxysalicylate
- Packaging
- 25g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- JK126763
- Product name
- Methyl 4-Methoxysalicylate
- Purity
- 98%
- Packaging
- 50g
- Price
- $183
- Updated
- 2021/12/16
Methyl 4-methoxysalicylate Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystalline powder
Uses
Methyl 4-methoxysalicylate (methyl 2-hydroxy-4-methoxybenzoate) was used in the enantioselective synthesis of (+)-coriandrone A and B, two bioactive natural products.
Synthesis
121-98-2
5446-02-6
General procedure for the synthesis of methyl 4-methoxysalicylate from methyl 4-methoxybenzoate: Ru(MesCO2)(L) (p-cymene) [L=2,2'-bipyridine or 4,4'-dibromo bipyridine] (2.5 mol%), oxidizing agent (2.0 eq.), and methyl 4-methoxybenzoate (1.0 eq.) were added to a sealed tube. Subsequently, a mixture of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA) in the ratio of 0.6 mL:0.4 was added. The reaction mixture was placed in an oil bath preheated to 110 °C and stirred until the reaction was complete, and the reaction process was continuously monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched by the addition of ice water and extracted with dichloromethane. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated by rotary evaporator. Finally, the residue was purified by silica gel column chromatography to afford the target product methyl 4-methoxysalicylate.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 38, p. 3743 - 3746
Methyl 4-methoxysalicylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-methoxysalicylate manufacturers
- Product
- Methyl 4-methoxysalicylate 5446-02-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- 4-methoxymethylsalicylate 5446-02-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-09-18
- Product
- Methyl 4-methoxysalicylate 5446-02-6
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23